化妆品对皮肤刺激试验的病理分析  

Pathological analysis of irritation of cosmetic to skin

作　　者：黄明芳[1] 高青[1] 孟慧林[1] 郭润荣[1] 徐凤丹[1] 秦钰慧[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,中国预防医学科学院环境卫生监测所

出　　处：《卫生研究》1994年第5期281-282,共2页Journal of Hygiene Research

摘　　要：对２１０份化妆品皮肤刺激试验的病理诊断结果作了分析，病理反应积分为０者４９份，占２３．３３％，病理反应积分１～４者７５份，占３５．７１％，病理反应积分＞４者８６份，占４０．９５％；在收集到的８４０份皮肤标本中，有病理反应的５２０份，占６１．９０％，皮肤的反应以表皮和真皮同时出现改变较为多见，占５０．７７％，其次是单纯表皮反应，占３５．３８％，单纯真皮反应仅占１３．８５％；表皮反应以棘层肥厚最多见，真皮反应以真皮炎细胞浸润为主。Pathological reaction of irritation of 210 cosmetic specimens to skin was analysed. The score of cumulative pathological reaction of 49 specimens is 0 (23. 33%), 75 specimens is 1～4 (35. 71%) and 84 specimens 1s > 4 (40. 95%). In the collected 840 skin samples, pathological reaction was detected in 520 samples (61. 90%). The changes observed simultaneously in epidermis and corium were the common forms of skin reactiOn, the change of epidermis and corium alone is respectively 35. 38% and 13. 85%. Acanthosis is the main pathological change of epidermis, accounting for 69. 20% of the total epidermis change. Secondly, hyperkeratosis, hypergranulosis and acanthosis were found simultaneously in epidermis, which account for 26.34% of epidermis change. Infiltration of inflammation cells is the common pathological change of corium (63. 69%). Infiltration and congestion account for 26. 19% of corium change. Institute of Environment Health Monitoring. Chinese Academy of Preventive Medicine

关 键 词：病理 化妆品 皮肤刺激试验 

分 类 号：TQ653[化学工程—精细化工]