血清可溶性细胞间粘附分子-1和E-选择素水平与冠心病的关系  

The correlation between the serum soluble ICAM-1 and E-Selectin and coronary heart disease

作　　者：饶丹 姜红[2] 曾秋棠[3] 郭和平[3] 王敏[3] 李明慧[3] 

机构地区：[1]湖北省武汉市第八医院心内科,430010 [2]上海复旦大学附属中山医院心内科 [3]华中科技大学同济医学院心血管病研究所

出　　处：《临床内科杂志》2005年第3期177-179,共3页Journal of Clinical Internal Medicine

基　　金：教育部留学人员回国基金资助项目教外司留[2002 ] 247

摘　　要：目的　比较冠心病(CHD)患者血清可溶性细胞间粘附分子- 1(sICAM -1)和血清可溶性E 选择素水平,探讨其临床意义。方法　145例冠心病患者,其中 73例为急性冠脉综合征组(ACS组), 72例为稳定型冠心病组 (SCHD组 ),并选 144名健康查体者作对照组。用酶联免疫吸附法(ELISA)检测血清sICAM -1、可溶性E 选择素水平,并比较上述指标水平在三组之间的差异。结果　血清sICAM -1浓度ACS组(320. 3±81. 8)μg/L和SCHD组(266. 5±63. 5)μg/L明显高于对照组(176. 3±78. 3)μg/L,P<0. 01,ACS组和SCHD组间也有显著性差异(P<0. 05)。血清可溶性E 选择素浓度ACS组(48. 5±12. 1)μg/L和SCHD组 (36. 1±11. 9)μg/L明显高于对照组(28. 8±10. 3)μg/L,P<0. 01,ACS组和SCHD组间也有显著性差异 (P<0. 05 )。结论　血清sICAM- 1、可溶性E 选择素在冠心病患者中明显高于对照组,其中ACS患者明显高于SCHD患者。Objective To compare the levels of serum soluble intercellular adhesion molecule-1 (sICAM-1) with soluble E-selectin (sE-selectin) and to discuss its role in coronary heart disease (CHD) patients.Methods We measured levels of serum sICAM-1 and sE-selectin among 145 CHD including 73 acute coronary syndrom (ACS) patients,72 stable coronary heart disease (SCHD) patients and 144 controls by enzyme-linked immunosorbent assay(ELISA).Results Serum sICAM-1 levels in group ACS (320.3±81.8)μg/L and in group SCHD (266.5±63.5)μg/L were significantly higher than those in controls(176.3±78.3)μg/L(P<0.01),whereas in group ACS is higher than those in group SCHD(P<0.05).Serum sE-selectin levels in group ACS (48.5±12.1)μg/L and in group SCHD (36.1 ±11.9)μg/Lwere significantly higher than those in controls (28.8±10.3)μg /L(P<0.01),whereas in group ACS is higher than those in group SCHD(P<0.05).Conclusion The levels of sICAM-1 and sE-selectin in CHD patients were significantly higher than controls and those in group ACS were significantly higher than in group SCHD.

关 键 词：冠心病 血清可溶性细胞间粘附分子-1 血清可溶性E-选择素 

分 类 号：R541.4[医药卫生—心血管疾病]