钾通道开放剂烟酰胺对急性心肌梗死患者血浆内皮素及心功能的影响  

The effect of potassium channel opener Nictinamide on cardiac function and endotheline in patients with AMI

作　　者：张素荣[1] 陈志刚[1] 吕风华[1] 

机构地区：[1]新乡医学院第一附属医院心血管内科,河南新乡市453100

出　　处：《中国心血管病研究》2005年第3期178-180,共3页Chinese Journal of Cardiovascular Research

基　　金：河南省科技攻关基金资助项目(0224630057)

摘　　要：目的探讨钾通道开放剂烟酰胺对急性心肌梗死患者血浆内皮素及心功能的影响。方法入选94例急性心肌梗死患者,随机分为烟酰胺治疗组(治疗组)48例,常规治疗组(对照组)46例,测定两组急性心肌梗死患者治疗前后血浆内皮素(ET),左室射血分数(LVEF)及左室收缩末期容量(LVESV)变化。结果 治疗组:与治疗前自身比较,治疗后血浆ET明显降低,LVEF明显增加,LVESV降低(P<0.01)。对照组:治疗后血浆ET无明显变化(P>0.05),LVEF、LVESV也有改善。治疗组与对照组比较治疗后各项指标均有显著性差异(P<0.01)。结论烟酰胺可改善心肌梗死患者内皮细胞功能,减少ET的分泌和释放,增加左室射血分数和降低左室收缩末期容量,改善心功能。Objective To evaluate the effect of the potassium channel opener Nictinamide on the serum Endotheline(ET) and cardiac function in patients with AMI . Methods A total of 94 cases patients with AMI Were divided randomly into two graups ,one was Nictinamide treatment group (the treatment group n=48), an other was regular treatment (the control group n=46). All the patients Were obserued the changes of cardic function and ET . Results after treatment LVESV reduced signiticantly . (p<0.01=and LVEF increased evidently (P<0.01= in both groups .ET reduced signiticantly (P<0.01= in the treatment group but no difference in the control group (P>0.05) . Conclusion Nictinamide can reduce the level of endotheline in AMI patients.

关 键 词：心肌梗死 烟酰胺 内皮素 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]