蒙古族冠心病患者血浆纤溶活性的研究  

The Study Of The Changes Of Plasm Fibrinolysis Activity In Mongolian Patients With Coronary Heart Disease

作　　者：闫旭龙[1] 孙刚[1] 贾纪荣[1] 吴国霞[1] 王增帅[1] 刘雅楠[1] 

机构地区：[1]内蒙古科技大学第二附属医院心内科,内蒙古自治区包头市014030

出　　处：《中国心血管病研究》2005年第3期184-187,共4页Chinese Journal of Cardiovascular Research

基　　金：包头市自然科学基金项目(2002121)

摘　　要：目的研究蒙古族冠心病(CHD)发病与血浆纤溶活性变化的关系。方法分别采集32例蒙古族CHD患者、30例蒙古族无CHD者(对照组),41例汉族CHD患者、55例汉族正常人(对照组)晨起空腹静脉血,肝素抗凝后冷冻保存。t-PA、PAI-1含量通过酶联免疫吸附双抗体法(ELISA);Fbg通过抗原-抗体复合物法测定。结果蒙古族CHD组、蒙古族对照组、汉族CHD组、汉族正常组的年龄与Fbg、t-PA、PAI-1无相关性。无论是蒙古族CHD组还是汉族CHD组血浆PAI-1、PAI-1/t-PA值均比无CHD的对照组低,而Fbg、t-PA值比较均无统计学意义;蒙古族CHD组的t-PA、PAI-1/t-PA值较汉族CHD组低,Fbg值高,而PAI-1无统计学意义;在蒙古族CHD组与汉族正常组比较中,Fbg、PAI-1、PAI-1/t-PA有意义;而两个对照组之间的比较,只发现t-PA、PAI-1/t-PA有统计学意义。结论CHD患者血浆纤溶活性降低,主要与PAI-1水平增高有关;蒙古族CHD患者较汉族CHD患者血浆纤溶活性降低,主要与t-PA水平降低及Fbg水平增高有关;蒙古族对照组较汉族对照组血浆纤溶活性降低,主要与t-PA水平降低有关。Objective To investigate the changes of plasm fibrinolysis activity in Mongolian patients with coronary heart disease(CHD). Methods Fasting venous blood was drawn from 30 Mongolian CHD patients, 32 Mongolian control subjects,41 Han CHD patients and 55 Han health people. Their fibrillogen(Fbg),tissue plasminogen activitor(t-PA), plasminogen activitor inhibitor 1(PAI-1) assays were performed by enzyme linked immunosorbent assay(ELISA) and immune complex assay. Results There are no correlation between age and Fbg, t-PA,PAI-1 in every team . Both Mongolian and Han CHD patients have an higher lever of PAI-1, PAI-1/ t-PA than Mongolia and Han control groups,p<0.05,but no statistical significances is in Fbg and t- PA,p>0.05.The t-PA of the Mongolian CHD group is lower than those of the Han CHD group, and Fbg, PAI/t-PA is higher than it,p<0.05. In the Mongolian CHD group comparing with the Han health group, the statistical significances exist in Fbg, PAI-1, PAI-1/t-PA,p<0.05. At last, we only found that the Mongolian control group had lower levers of t-PA, and higer lever of PAI-1/t-PA than the Han control group,p<0.05. Conclusion The main reason why plasm fibrinolysis activity in CHD patients decreases is increase of PAI-I.Mongolian CHD patients have higher Fbg and lower t-PA levers than Han CHD patiens. Becuase of the low t-PA, Mongolian fibrinolysis activity is lower than Han.

关 键 词：蒙古族 冠心病 血浆纤溶活性 

分 类 号：R541.4[医药卫生—心血管疾病]