血清叶酸与冠状动脉支架内再狭窄关系的研究  

Evaluation of the serum level of falate on the coronary in-stent restenosis

作　　者：黄进[1] 汤涌[1] 贾海波[2] 刘志忠[2] 陈绍良[2] 杜同心[3] 

机构地区：[1]南京胸科医院心内科,江苏南京市210029 [2]南京第一医院心内科 [3]南京市医学放射免疫检测中心

出　　处：《中国心血管病研究》2005年第3期194-195,共2页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨冠状动脉支架内再狭窄与血清叶酸水平的关系。方法选择资料齐全的86例冠心病支架术后患者,根据造影结果分再狭窄组与非再狭窄组。运用放射免疫法测定血清叶酸浓度。对支架术后两组血清叶酸水平进行对比分析。结果两组在年龄、性别、高血压的发生率无统计学意义,但吸烟、合并糖尿病者再狭窄发生率明显高于非再狭窄者(P<0.01),再狭窄组血清叶酸明显低于非再狭窄组(P<0.05)。结论资料提示:年龄、性别、高血压等对支架的再狭窄无明显影响,吸烟、糖尿病患者再狭窄发生率明显增加;且支架内再狭窄者叶酸水平明显降低。Objective To evaluate the clinical and the serum level of falate on the coronary in-stent restenosis. Methods Eighty six patients whose data were available were enrolled in this study, and the patients were divided into the groups of in-stent restenosis and non in-stent restenosis according to the results of coronary angiograms. The serum level of falate was measured by radioimmunology. Then the clinical and the serum level of falate in two groups were analyzed. Results There were no statistical differences in age, sex and hypertention between two groups. Smoking and diabetes mellitus in the group of in-stent restenosis was more severe than that in the group of non in-stent restenosis (P<0.01=. The serum level of falate in the group of in-stent restenosis was obviously lower than that in the group of non in-stent restenosis (P<0.05=. Conclusion The results suggested that the rate of in-stent restenosis was not significantly influenced with age, sex and hypertention, but smoking and diabetes mellitus were positibely related to in-stent restenosis. The level of falate was negative related to in-stent restenosis.

关 键 词：冠状动脉支架术 再狭窄 叶酸 

分 类 号：R543.3[医药卫生—心血管疾病]