氯沙坦与依那普利对原发性高血压病人肾功能的影响  

Effects of Losartan and Enalaprol on renal function in patients with Essential Hypertension

作　　者：郭旭梅[1] 陈步星[1] 李惠玲[2] 毕隽芳 李杰[2] 

机构地区：[1]北京电力医院心内科,北京100073 [2]邯郸市第一医院 [3]北京市1048信箱门诊部

出　　处：《中国心血管病研究》2005年第3期202-204,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的观察氯沙坦和依那普利对伴有微量白蛋白尿的原发性高血压病人早期肾病的治疗作用。方法80例原发性高血压病人随机分两组,其中氯沙坦组40例,剂量50～100mg·d-1,依那普利组40例,剂量10～20mg·d-1,治疗8周。治疗第0、4和8周末测血压、心率;第0、8周测血肌酐(Scr)、尿肌酐并计算内生肌酐清除率(Ccr)以及尿微量白蛋白(ALB)、β2微球蛋白(β2-MG)水平。结果血肌酐和内生肌酐清除率两组间比较无统计学意义(P>0.05),尿微量白蛋白、β2微球蛋白氯沙坦组较治疗前分别下降了34.7%和24.5%,治疗前后比较差异有显著性(P<0.01);依那普利组分别下降了38.2%和24.8%,治疗前后比较差异亦有统计学意义(P<0.01);而两组间差值比较差异无统计学意义(P>0.05)。结论氯沙坦不仅降低血压而且降低尿微量白蛋白及尿β2微球蛋白水平,与依那普利相比具有同样的保护肾功能作用。Objective To observate the effect of losartan and enalaprol on the treatment of urine microalbuminuria in patients with essential hypertension. Methods eighty patients with essential hypertension were randomly divided into two groups. losartan group(n=40) recieved losartan 50～100mg, po, qd for 8wk, and enalaprol group(n=40) received enalaprol 10～20mg, po, qd for 8wk. Results The serum creatinine and creatinine clearance rate had no significant difference between losartan droup and enalaprol group (P>0.05). But end of 8wk, the urine microalbuminuria and β2-microglobulin all decreased in two groups. Losartan group decreased 34.7% and 24.5% respectively, and enalaprol group decreased 38.2% and 24.8% respectively. There was no significant difference between losartan group and enalaprol group (P>0.05). Conclusion Losartan not only reduced blood pressure but also decreased the levels of urine microalbuminuria and β2-microglobulin and had same protection effects on renal function compared with enalaprol.

关 键 词：氯沙坦 依那普利 高血压 微量白蛋白 Β2微球蛋白 

分 类 号：R544.1[医药卫生—心血管疾病]