转化生长因子β_1和胰岛素样生长因子1与原发性高血压左室重构的关系  

THE ASSOCIATION OF TGF-β_1 AND IGF-1 WITH LEFT VENTRICULAR REMODELING IN ESSENTIAL HYPERTENSION

作　　者：隋向前[1] 杨成悌[1] 张缤[1] 刘欣跃[1] 林文果[1] 赵锋[1] 

机构地区：[1]兰州医学院第二附属医院心内科,甘肃兰州市730030

出　　处：《中国心血管病研究》2005年第3期222-224,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨转化生长因子β1(TGF-β1)、胰岛素样生长因子1(IGF-1)与原发性高血压(EH)左室重构的关系。方法EH组59例,对照组29例。同步检测血中TGF-β1、IGF-1、血管紧张素Ⅱ(AngⅡ)、醛固醇(ALD);用超声心动图仪测定并计算左室重量指数(LVMI)。比较两组间上述指标的差异并分析EH组LVMI与其他指标的相关性。对相关的指标行Logistic回归分析。结果EH组血中TGF-β1水平较对照组降低(P<0.01);AngⅡ、ALD水平均较对照组增高(P<0.01)。在EH组中,IGF-1及AngⅡ是左室肥大的独立危险因素(OR=1.008,1.081;P=0.020,0.020)。结论EH患者左室重构与血中的IGF-1、AngⅡ水平有关,而与TGF-β1水平无关。Objective To study the association of transforming growth factor beta 1(TGF-β1), insulin-like growth factor 1(IGF-1) with left ventricular remodeling in essential hypertension(EH). Methods To detect serum TGF-β1, IGF-1, AngⅡ, ALD, and to calculate left ventricular mass index (LVMI) in 59 patients with EH and in 29normal subjects. Results The levels of TGF-β1 in EH group were lower than that in normal subjects(P<0.01= . The levels of AngⅡ, ALD in EH group were much higher than that in normal subjects(P<0.01=.In EH group , IGF-1, AngⅡ were independent factors of left ventricular hypertrophy (OR=1.008,1.081;P=0.020,0.020). Conclusion Serum IGF-1, AngⅡwere associatied with left ventricular remodeling but TGF-β1 in EH.

关 键 词：高血压 转化生长因子Β1 胰岛素样生长因子1 左室重构 

分 类 号：R544.1[医药卫生—心血管疾病]