氟砷联合中毒患者无机元素和胶原代谢状况观察  

Observation on Mineral Element and Collagen Metabolism of Patients with Combined Fluoride-arsenic Poisoning

作　　者：张婕[1] 冀芳[1] 薛茜[1] 孙莲[2] 邵红[1] 姜平[1] 刘文亚[3] 张跃新[3] 姚华[1] 刘开泰[4] 

机构地区：[1]新疆医科大学公共卫生学院 [2]新疆医科大学基础医学院 [3]新疆医科大学第一附属医院,乌鲁木齐830054 [4]新疆医科大学

出　　处：《地方病通报》2005年第1期21-23,共3页Endemic Diseases Bulletin

基　　金：国家自然科学基金项目(30160079)

摘　　要：目的观察改水后地方性氟中毒、氟砷联合中毒患者无机元素和胶原代谢的改变。方法　用氯胺T法测定尿羟脯氨酸含量;用氟离子选择电极法测定尿氟含量;用二乙氨基二硫代甲酸银法测定尿砷含量;用BairdPS-4型等离子体光谱仪测定尿中钾、钠、钙、磷、镁、锌含量;用美国BECKMAN公司LX20型全自动生化分析仪检测血清中钙、磷、镁、锌、铁含量。结果　各组之间尿氟、砷、HOP/Cr、钠、钾和血清钙、镁含量的差别均有统计学意义 (P<0. 05)。结论　单纯氟中毒和氟砷联合中毒所致人体的无机元素和胶原代谢紊乱在脱离高氟高砷暴露 20年后不能完全纠正,氟砷联合中毒患者体内无机元素和胶原代谢紊乱的恢复比单纯氟中毒患者更缓慢。Objective In order to observe the changes of mineral elements and collagen metabolism products of patients with endemic fluorosis and combined fluoride-arsenic poisoning. Methods Sixty-nine cases with skeletal fluorosis from endemic fluorosis area, 39 cases with combined fluoride-arsenic poisoning from endemic combined fluoride-arsenic poisoning area and 25 cases as the control from neither endemic fluorosis nor arsenism areas in Xinjiang were chosen to detect HOP, Cr and As in urine with biochemical methods. Fluoride in urine was determined with electrode method. K, Na, Ca, P, Mg and Zn in urine were examined by ICP. Ca, P, Mg, Zn and Fe in serum were examined by BECKMAN LX20 clinical system. Results The significant differences of F, As, K, Na, HOP/Cr in urine and Ca, Mg in serum were found in three groups(P<0.05). Conclusions The patients with fluorosis and combined fluoride-arsenic poisoning having changes of mineral elements and collagen metabolism products can not recover absolutely even if terminating high level fluoride and arsenic exposure.

关 键 词：氟中毒 氟砷联合中毒 

分 类 号：R599.9[医药卫生—内科学] R124.3[医药卫生—临床医学]