新烟碱类农药中间体乙酰基恶二嗪的合成  

Synthesis of 3-Acetyl-4-nitroimino-perhydro-1,3,5-oxadiazine as an Intermediate for New Nicotinyl Pesticides

作　　者：康铁牛[1] 凌云[1] 佘永红 陈馥衡[1] 杨新玲[1] 

机构地区：[1]中国农业大学应用化学系,北京100094 [2]沙隆达郑州农药有限公司,郑州450000

出　　处：《农药》2005年第3期108-109,共2页Agrochemicals

摘　　要：对农药重要中间体乙酰基-4-硝基亚氨基-1,3,5-恶二嗪的合成进行了研究,探讨了溶剂、时间、温度、物料配比等因素对反应收率的影响。最佳反应条件为1mol4-硝基亚氨基-1,3,5-恶二嗪与1.2mol乙酰氯以DMF为溶剂、在5℃￣10℃下反应10h,收率80%。并得到了与文献报道理化性质完全不同的产物,结构经IR、1HNMR和元素分析确证。Research was conducted on the synthesis of an important pesticide intermediate, 3-acetyl-4-nitroimino- perhydro-1,3,5-oxadiazine. The influence of several factors on reaction efficiency were determined, including solvent, time, temperature, and component ratios. Optimum reaction conditions were obtained by combining 1 mole of 4- nitroimino-perhydro-1,3,5-oxadiazine with 1.2 mole of acetyl chloride, using DMF as solvent. At 5 to10℃ and a 10- h reaction time, recovery was 80%. The product had chemical and physical properties completely different from analogous compounds previously reported. Chemical structure was confirmed by H NMR, IR, and elemental analysis. 1

关 键 词：烟碱 乙酰基恶二嗪 合成 

分 类 号：TQ25[化学工程—有机化工] TQ450