乙草胺对映体的手性识别  

Chiral Recognition of Acetochlor Enantiomers

作　　者：王鹏[1] 江树人[1] 刘东晖[1] 王萍[1] 姜伟[1] 周志强[1] 

机构地区：[1]中国农业大学理学院应用化学系,北京100094

出　　处：《农药》2005年第3期113-114,共2页Agrochemicals

基　　金：国家自然科学基金资助项目(20377052)

摘　　要：乙草胺对映异构体在纤维素衍生物手性固定相上得到了分离,分离系统为高效液相色谱,流动相为正己烷和石油醚,流动相中添加了乙醇、丙醇、异丙醇和丁醇为极性改性剂,考察了各种改性剂及其含量对拆分的影响。在0℃￣25℃范围内研究了温度对拆分的影响。试验结果显示,丙醇和丁醇在2%￣15%含量范围内对乙草胺没有分离效果,乙醇和异丙醇有一定的分离效果。流动相中醇含量的减少及温度的降低有利于对映体的拆分,在异丙醇含量为2%,温度为0℃时有最佳的分离效果,分离因子为1.20。Acetochlor enantiomers were separated using high performance liquid chromatography (HPLC) with a cellulose derivative fixed phase. The mobile phase was n-hexane or petroleum ether with the additives ethanol, propanol, 2-propanol, and butanol serving as polar modifiers. The influence on separation of these modifiers and their concentration was investigated across a temperature range of 0-25℃. Propanol and butanol at 2-15% provided no separation, while ethanol and 2-propanol provided some separation. Reducing alcohol concentration and temperature facilitated separation. Best separation results were obtained with 2% 2-propanol at 0℃, yielding a separation factor of 1.20.

关 键 词：乙草胺 对映体 高效液相色谱 手性拆分 

分 类 号：TQ457.2[化学工程—农药化工]