缬沙坦治疗扩张型心肌病心力衰竭的疗效观察  

CLINICAL EFFECTS OF VALSARTAN TREATMENT OF HEART FAILURE OF DILATED CARDIOMYOPATHY

作　　者：王东方[1] 李永峰[1] 程学华[1] 

机构地区：[1]河南省安阳地区医院心脑血管病区,河南安阳455000

出　　处：《河北医科大学学报》2005年第2期89-90,共2页Journal of Hebei Medical University

摘　　要：目的 观察血管紧张素Ⅱ受体拮抗剂(angiotension Ⅱ receptor blocker, ARB)治疗扩张型心肌病(dilated cardiomyopathy,DCM)心力衰竭的临床疗效。方法 随机分组对照分析 15 例用 ARB和 15 例用血管紧张素转换酶抑制剂(angiotension converting enzyme inhibitor,ACEI)抗心力衰竭治疗3个月的DCM心力衰竭患者临床资料及心肾功能变化。结果 治疗前两组间心率、左室舒张末内径、左室射血分数比较差异无显著性意义(P>0.05);经治疗后3个月,两组心率、左室舒张末内径、左室射血分数较治疗前均有明显改善(P<0.01);治疗后两组间比较ACEI组与ARB组心率、左室舒张末内径、左室射血分数无显著性差异(P>0.05)。结论 ARB可改善DCM心力衰竭患者的临床症状及心功能,减缓心力衰竭的病程发展,可作为ACEI副作用不能耐受者的替代治疗。ObjectiveTo clarify the clinical efficacy of Angiotension Ⅱ receptor-blocker(ARB) in patients with chronic congestive heart failure of dilated cardiomyopathy(DCM). MethodsThe study was designed to be two groups, group 1 with ARB treatment,group 2 with angiotension converting enzyme inhibitor(ACEI) treatment.Three months follow-up was done focused on the clinical manifestation and the dynamic functions of heart and kidney. ResultsIn comparison with the baseline values,after 3 months treatment,there was a significant improvement of heart rate,left ventricular ejective fraction and left ventricular diastolic diameter (P<(0.01)).There was no difference between two groups after treatment(P>(0.05)). ConclusionValsartan can improve cardiac function and clinical symptom of patients with DCM and resist the development of congestive heart failure.The patients without tolerant ACEI can be treated with valsartan.

关 键 词：心肌病 充血性 受体 血管紧张素 心力衰竭 充血性 

分 类 号：R542.2[医药卫生—心血管疾病]