环境铅暴露的新婚女性血铅水平与受孕时间的队列研究  

Effect of Environmental Lead Exposure on Time to Pregnancy of Newly-Married Women

作　　者：沈彤[1] 朱中平[1] 杨永坚[1] 胡传来[1] 余秋月[1] 郭智勇[1] 俞翠莲[2] 邹武庆[2] 刘俊玲 姜玉屏 朱启星[1] 

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]池州市疾病预防控制中心,安徽池州247100 [3]池州市贵池区妇幼保健所,安徽池州247100

出　　处：《环境与健康杂志》2005年第2期83-86,共4页Journal of Environment and Health

基　　金：安徽省教育厅科研基金资助项目(2003KJ179);安徽省高校省学术带头人科研基金资助项目(2002HBL10);安徽省计划生育科研项目(200204);安徽省卫生厅科研项目(2002B090)

摘　　要：目的研究环境铅暴露的新婚女性血铅水平对临床受孕时间(TTP)的影响。方法用前瞻性队列研究方法,对有环境铅暴露的准备怀孕的210对新婚夫妇建立研究队列,进行基线调查,采集静脉血进行血铅测定,并追踪至临床怀孕,计算TTP,分析血铅水平对TTP的影响。结果210例女性血铅几何均值±标准差为(62.71±2.18)μg/L,平均TTP为2.95个月经周期,随着TTP的延长,受孕率逐渐降低;女性高血铅组(≥100μg/L)和低血铅组(<100μg/L)TTP中位数分别为3.38、2.74个月经周期,TTP分布构成比差异有统计学意义(P<0.05);COX比例风险模型进行多元逐步回归分析显示,女性高、低血铅组受孕力比值(FR)为0.626(95%可信区间0.416～0.941),差异有统计学意义(P<0.05),表明女性血铅≥100μg/L时,受孕力可能下降。结论环境铅暴露对TTP可能有不良影响。Objective To study the effect of environmental lead exposure on time to pregnancy(time to pregnancy, TTP) of newly-married women. Methods Cohort study was conducted among the newly-married couples who had been living in the area polluted by lead for more than one year before the investigated womem became pregnancy. Before followed-up, baseline investigation were performed and blood lead levels were measured. The relationship between TTP and blood lead levels were analyzed by COX regression model. Results Geometric mean of 210 women blood lead levels was (62.71±2.18)μg/L,means of TTP was 2.95 menstral cycles, the fecundability was decreased with the TTP prolonged. The distribution of TTP between high and low lead groups of blood was significant different(P<0.05). Cox regression analysis showed two group fecundability ratio(FR) was 0.626(95% CI:0.416-0.941), the difference was significant. The result of the present paper indicated that fecundability discreased when the BBLL of woman was not less than 100 μg/L. Conclusion Environmental lead exposure has an adverse effect on TTP.

关 键 词：铅 环境暴露 生育力 

分 类 号：R181.3[医药卫生—流行病学]