高效液相色谱手性固定相法直接拆分外消旋四面体金属簇合物  

Direct Chiral Separation of Racemic Tetrahedral Metal Clusters by Chiral Stationary Phase-HPLC

作　　者：韩小茜[1] 李刚[1] 赵丽[1] 刘俊[1] 李军[1] 殷元骐[2] 陈立仁[2] 

机构地区：[1]兰州交通大学化学与生物工程学院,甘肃兰州730070 [2]中国科学院兰州化学物理研究所,甘肃兰州730000

出　　处：《分析测试学报》2005年第2期38-40,共3页Journal of Instrumental Analysis

基　　金：兰州交通大学"青蓝人才工程资助计划"资助项目; 甘肃省教育厅资助(O316B-03)

摘　　要：在自制的涂敷型纤维素_三(3, 5-二甲基苯基氨基甲酸酯)手性固定相上直接拆分了含金属镍的外消旋四面体金属簇合物, 得到了满意的色谱分离结果。同时考察了流动相中极性改性剂———醇的种类及结构对手性拆分的影响。结果发现, 被研究的外消旋四面体金属簇合物在正丁醇作流动相极性改性剂时拆分效果好。The chiral separation of racemic tetrahedral metal clusters was directly performed on a self-made cellulose-tris(3,5-dimethylphenylcarbamate)(CDMPC-CSP)chiral stationary phase with satisfactory reˉsults.The influences of the alcoholic type mobile phase modifier in the mobile phase and the structures of chiral tetrahedral type metal clusters on the chiral separation and retention were studied.It was found that the structure and alcohol concentration in mobile phase and the subtle structural differences in racemic could have a pronounced effect on enantiometric separation and retention.The chiral separation of racemic tetraheˉdral metal clusters was most effective when using n-butanol as mobile phase modifier.

关 键 词：高效液相色谱 手性固定相 纤维素一三(3 5一二甲基苯基氨基甲酸酯) 外消旋四面体金属簇合物 手性拆分 极性改性剂 

分 类 号：O658[理学—分析化学]