小分子RNA家族中的新成员——microRNA  

A Novel Member of Small RNA Family-microRNA

作　　者：杨立霞[1] 黄胜和[1] 沈银柱[1] 黄占景[1] 

机构地区：[1]河北师范大学生命科学学院,河北石家庄050016

出　　处：《河北师范大学学报（自然科学版）》2005年第2期185-189,共5页Journal of Hebei Normal University：Natural Science

基　　金：河北省自然科学基金资助项目(303152)

摘　　要：近来,人们在多种生物中发现了一类新的小分子RNA———microRNA(miRNA).miRNA是20～24nt的单链RNA,在进化上具有高度的保守性,它通过与靶mRNA不完全互补配对,抑制蛋白翻译,调节内源基因表达,在基因调控中扮演了重要的角色.miRNA和siRNA(smallinterferenceRNA)在生成机制、作用途径等方面关系密切,它们既有区别又相互联系.小分子RNA的研究将是今后分子生物学的研究热点之一.Recently,a class of small RNA have been identified in a variety of organisms.These small RNAs,called miRNA (microRNA),are 21～24 nt single-stranded RNA,which keep high conservation in the process of evolution.They regulate gene expression and inhibit protein synthesis by binding to partially complementary 3′ untranslated regions (3′ UTRs) of target mRNA.Some miRNA have been shown to play critical roles in gene regulation.There are many affinities in processing mechanism and functional approach between miRNA and siRNA.MiRNA distinct from but related to siRNA.The recent advance of miRNAs is reviewed.

关 键 词：MIRNA 时序调控 SIRNA 小分子RNA 

分 类 号：Q52[生物学—生物化学]