壳聚糖-聚乙二醇接枝共聚物的合成与表征  

Synthesis and Characterization of Graft Copolymer of Chitosan and Polyethylene Glycol

作　　者：孙毅毅[1] 侯世祥[1] 陈彤[1] 何军[1] 袁子雁[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《四川大学学报（工程科学版）》2005年第2期76-79,104,共5页Journal of Sichuan University (Engineering Science Edition)

摘　　要：用1,1'羰基二咪唑活化MPEG法制备活化MPEG,再用活化MPEG与壳聚糖上的伯氨基反应,两步法合成了壳聚糖-聚乙二醇接枝共聚物。用FT-IR、1H-NMR对共聚物的结构进行了表征,分别用重量法、间接法及1H-NMR测定了接枝率约为11%,符合经典隐形纳米粒材料的PEG含量。用X-射线衍射及DSC证明了聚合物的结晶度有所增强,有望作为隐形纳米粒的载体材料使用。为长循环及实体瘤给药系统研究提供新的载体奠定了基础。MPEG was modified with 1,1'-carbonyldiimidazole, then the activated MPEG reacted with primary amino groups of chitosan. Synthesize the graft copolymer of chitosan and polyethylene glycol in two steps. The structure of the copolymer was characterized by FT-IR and 1H-NMR. The graft rate was determined to be 11% with gravimetry method, indirect method and 1H-NMR. It agrees with the PEG content of classical stealth nanoparticles materials. The X-ray diffraction and DSC analyses proved that the crystallinity of the copolymer increased. It is a promising material for the stealth nanoparticles. It is a potential new carrier for the drug delivery systems of long-circulation and solid carcinoma.

关 键 词：壳聚糖 单甲氧基聚乙二醇 接枝共聚物 隐形纳米粒 载体材料 

分 类 号：TQ322.9[化学工程—合成树脂塑料工业]