异黄酮对雄性大鼠芳香化酶活性及骨骼肌生长的影响  

Effectsofisoflavoneonaromataseactivityandmusclegrowthinmalerats

作　　者：马海田[1] 韩正康[1] 王国杰[1] 邹思湘[1] 

机构地区：[1]南京农业大学农业部动物生理生化重点开放实验室,江苏南京210095

出　　处：《南京农业大学学报》2005年第1期76-79,共4页Journal of Nanjing Agricultural University

基　　金：国家自然科学基金资助项目 (39970534)

摘　　要：研究 3种异黄酮 (Da、IPF和 7HF) 对雄性大鼠芳香化酶活性及骨骼肌生长的影响。试验选用 20只 28日龄雄性SD大鼠, 随机分成 4组, 每组 5只, 其中 1组为对照组, 另外 3组在每千克日粮中分别添加 5mg的Da、IPF和 7HF。实验结果表明, Da、IPF和 7HF均能升高腿肌中RNA/DNA的比值, 分别较对照组升高了 19 09%、9 09%和 15 45%;同时显著增加血清中睾酮的含量, 降低血清中雌二醇的含量, 抑制睾丸组织中芳香化酶的活性。提示异黄酮 (Da、IPF、7HF) 通过抑制芳香化酶活性而降低睾酮向雌二醇的转化, 使体内睾酮含量升高, 有助于促进动物的生长发育。Taunty Sprague-Dawley rats of 28 day-old were fed diet,supplemented with daidzein,ipriflavone and 7-hydroxyisoflavone at 5 mg·kg -1 respectively,and at 0 mg·kg -1 in the control group.Compared with that control group,daidzein,ipriflavone and 7-hydroxyisoflavone could increase the ratio of RNA/DNA in the leg muscle by 19.09%,9.09% and 15.45%,respectively.Meanwhile,the level of testosterone was increased and the level of estradiol decreased with aromatase activity alleviated.These results indicate that daidzein,ipriflavone and 7-hydroxyisoflavone could promote the animal′s growth by inhibiting the activity of aromatase which reduces the conversion of testoterone to estradiol and increases the content of testoterone in the serum.

关 键 词：异黄酮 雄性大鼠 芳香化酶 肌肉生长 

分 类 号：S813.24[农业科学—畜牧学]