冠心病患者循环血中NO和vW因子的变化  

Changs of nitric oxide and von Willebrand factor levels in serum of patients with coronary heart disease ospital of CangM

作　　者：张新华[1] 孙坚[1] 胡申江[1] 徐根云[2] 

机构地区：[1]浙江大学医学院附属第一医院心内科,杭州310003 [2]浙江大学医学院附属第一医院检验科,杭州310003

出　　处：《浙江医学》2005年第3期169-170,F003,共3页Zhejiang Medical Journal

摘　　要：目的探讨冠状动脉粥样硬化性心脏病(简称冠心病,CHD)患者血液循环中一氧化氮(NO)和血管性假血友病因子(vWF)含量的变化。方法分别应用硝酸酶还原法和ELISA法测定38名正常人和39名CHD患者的血清NO、vWF因子及血脂的含量。结果CHD患者血清NO含量为(56.3±21.0)μmol?l,显著低于正常对照组(79.7±21.1)μmol?l(t=4.41,P<0.001);CHD患者的血浆vWF因子含量(182.0±21.0)%显著高于正常对照组(142.0±24.0)%(t=7.34,P<0.001)。结论CHD的发生可能与NO的减少和vWF的增加有关。Objective To investigate the relationship between the changes of serum nitric oxide (NO) and plasma von Willebrand factor(vWF) levels and the pathogenesis of coronary heart diseases(CHD). Methods The serum NO levels were determined by enzymatic assay with nitrate reductase, and the plasma vWF levels were determined by enzyme-linked immunosorbent assay(ELISA)in 38 healthy subjects and 39 patients with CHD. Results The mean serum concentration of NO in patients was 56.3±21.0μmol L, much lower than that of healthy subjects (79.7±21.1μmolL)(t=4.41,P<0.001). The plasma vWF levels were significantly higher in patients than those in controls.(181±21)vs(142±24)%, t=7.34,P<0.001. Conclusion The decreased NO and increased vWF levels in CHD patients might be involved in the pathogenesis of arteriosclerotic heart disease.

关 键 词：CHD 冠心病患者 VW因子 VWF因子 对照组 循环血 正常 一氧化氮(NO) 变化 简称 

分 类 号：R541.4[医药卫生—心血管疾病] R512.62[医药卫生—内科学]