睡眠鼾症患者血清内皮素和一氧化氮测定及其临床意义  

Clinical significance of plasma Endothelin and Nitric Oxide in snoring patients

作　　者：刘加良[1] 朱巧英[1] 杨清萍[1] 

机构地区：[1]嘉兴市第一医院呼吸科,314000

出　　处：《浙江医学》2005年第3期178-179,182,共3页Zhejiang Medical Journal

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清内皮素(ET)、一氧化氮(NO)与高血压的关系。方法检测150例睡眠鼾症患者血清ET和NO水平,ET采用放射免疫法测定,NO采用硝酸还原酸法测定。结果轻度(n=53)、中度(n=21)、重度(n=20)OSAHS患者血清ET分别为(47±25)、(60±21)、(52±22)pg?ml,血清NO分别为(63±8)、(63±10)、(54±17)μmol?L。不同程度的OSAHS患者间血清ET差别无显著性意义(F=0.931,P>0.05);重度OSAHS患者血清NO降低(F=2.361,P<0.05),舒张压增高(F=3.520,P<0.05);但重度OSAHS伴与不伴高血压患者的血NO水平差别无显著性意义(F=-0.757,P>0.05)。结论重度OSAHS患者血清NO降低,舒张压增高,血ET和NO在OSAHS中引起高血压的作用可能不大。Objective To explore the relationship between Endothelin(ET), Nitric Oxide(NO)in obstructive sleep apnea-hypopnea syndrome (OSAHS) and hypertension. Methods To detect plasma ET and NO in 150 snoring patients with radioimmunity assay and nitric acid deoxidize assay severalty. Results Plasma ET and NO are(47±25)?(60±21)?(52±22)pgml and (63±8 )?(63±10) ?(54±17) μmolL respectively in light (n=53), moderate (n=21), heavy (n=20) groups. There is no significant difference for ET in variable OSAHS. There are marked descent for NO in heavy OSAHS(F=2.361,P<0.05). Diastolic pressure is higher in this group(F=3.520,P<0.05). But there is no statistical difference in heavy OSAHS with or without hypertension(F=-0.757,P>0.05). Conclusion There are lower NO and higher diastolic pressure in heavy OSAHS. ET and NO are probably not necessary in OSAHS with hypertension.

关 键 词：患者 OSAHS ET 血清内皮素 重度 鼾症 睡眠 显著性 目的 程度 

分 类 号：R56[医药卫生—呼吸系统]