早期干预对重度窒息新生儿脑保护作用的研究  

作　　者：顾勇[1] 姚泽忠[1] 

机构地区：[1]浙江省台州医院,317000

出　　处：《浙江临床医学》2005年第3期227-228,共2页Zhejiang Clinical Medical Journal

摘　　要：目的　 探讨应用苯巴比妥和复方丹参注射液早期干预对新生儿重度窒息的治疗和保护作用。 方法　 出生时呈重度窒息尚未出现惊厥的足月新生儿作为研究对象 ,随机分为三组 :非干预组、苯巴比妥干预组、苯巴比妥 +复方丹参干预组。观察指标包括惊厥、死亡率、住院时间、CT改变、预后等 ,追踪观察 1年以上。 结果　 苯巴比妥和苯巴比妥 +复方丹参干预组惊厥发生率明显低于非干预组 ;CT改变非干预组 1个月后明显高于干预组 ,3个月非干预组明显高于苯巴比妥 +复方丹参干预组 ;预后苯巴比妥 +复方丹参干预组明显优于非干预组和苯巴比妥干预组。死亡率和住院时间三组无明显差异。 结论　Objective To explore the significance of Phenobarbital and Compound Salvia Injection in treatment and protection of early severe perinatal asphyxia. Methods The term infants with severe perinatal asphyxia were selected as subjects.The subjects were divided into three groups: Phenobarbital group, Phenobarbital+Compound Salvia Injection group and control group. The convulsion, mortality, hospitalization time, change of the CT and prognosis were used as observation index. The results were analyzed by SPSS 11.0 for windows. Results Convulsion rates in Phenobarbital group and phenobarbital+ Compound Salvia Injection group were lower than control group. Manifestation of CT of control group changed more significant than intervention groups by 1 month,but by 3 month the result was adverse. The prognosis of Phenobarbital+ Compound Salvia Injection group were better significantly than the other two groups(P<0.05).Mortality in three groups was similar. Conclusion Phenobarbital and Compound Salvia Injection can reduce convulsion rates of infant with severe perinatal asphyxia and improve prognosis.

关 键 词：苯巴比妥 早期干预 惊厥 复方丹参 预后 脑保护作用 住院时间 结论 研究对象 目的 

分 类 号：R722.1[医药卫生—儿科]