军人应激相关障碍患者多种诱发电位的研究  

Correlative and followed-up study on brain evoked potentials of stress-related disorders

作　　者：甘景梨[1] 高存友[2] 胡兴焕[1] 李晓琼[1] 杨代德[2] 张伟红[1] 

机构地区：[1]解放军第91医院全军精神疾病防治中心精神科,焦作454003 [2]解放军第91医院全军精神疾病防治中心电生理学实验室,焦作454003

出　　处：《中国行为医学科学》2005年第3期252-254,共3页Chinese Journal of Behavioral Medical Science

基　　金：济南军区医药卫生计划课题(03j036)

摘　　要：目的探讨军人应激相关障碍(SRD)的诱发电位变异特点及其临床应用价值. 方法应用Nicolet Bravo脑诱发电位仪、症状自评量表(SCL-90)和事件影响量表(IES),对62例SRD患者(SRD组)和56名健康军人(对照组)进行了事件相关电位P300(P300)、听觉诱发电位(AEP)、视觉诱发电位(VEP)、SCL-90和IES的测定,并于治疗3、5个月时进行了随访. 结果治疗前与对照组比较,SRD组的P300-P3(345.0±16.3)ms、AEP-N2(244.8±27.5)ms和VEP-P2(201.3±32.3)ms潜伏期均延迟(P <0.05～0.01),P300-P3波幅(7.6±2.6)μV增高(P <0.01),AEP-P2波幅(3.6±1.8)μV降低(P ＜0.05);SCL-90总分及其强迫、抑郁、焦虑因子分,IES总分及回避、闯入因子分明显高于对照组(P ＜0.01),并与P300、AEP和VEP的潜伏期、波幅有相关性(P ＜0.05～0.01).治疗后与治疗前比较,SRD组P300-P3潜伏期前移、波幅降低(P ＜0.05和0.01),AEP-N2和VEP-P2潜伏期前移(P ＜0.05).治疗前后部分脑诱发电位的差值与临床量表评分的差值间呈显著性相关(P ＜0.05～0.01). 结论 SRD患者的诱发电位变化在一定程度上反映了临床症状改变,多项诱发电位指标联合应用可试作为军人SRD监测的一种客观指标.ObjectiveTo investigate the status and significance of brain evoked potentials (BEP) in patients with stress-related disorders (SRD). Methods Event related potential P 300 (P 300), auditory evoked potential (AEP) and visual evoked potential (VEP), Symptom Check List-90 (SCL-90) and Impact of Event Scales (IES) were recorded from 62 SRD patients by using a Nicolet Bravo Instrument, SCL-90 and IES, compared with that of 56 normal controls. SRD patients were followed up with the same markers after 3.5 months treatment. Results Compared with control group, SRD patients showed delayed latency of P 3/P 300, N 2/AEP and P 2/VEP, increased amplitude of P 3/P 300 and decreased amplitude of P 2/AEP. The mostly items of BEP were significantly related to clinical symptoms before treatment, and the change of BEP were significantly related to the alleviation of clinical symptom after treatment. The following up measures of BEP suggested that the latency of P 3/P 300, N 2 /AEP, P 2 /VEP, and the amplitude of P 3/P 300 might be state markers and the amplitude of P 2/AEP might be trait marker of SRD. Conclusion The clinical application of BEP in SRD is emphasized.

关 键 词：应激相关障碍 诱发电位 精神症状 军事人员 

分 类 号：R82[医药卫生—临床医学]