五倍子乙醇提取物对金葡菌的体外抗菌研究  

In- vitro Antibacterial Activity of Ethanol- Extract of Galla Chinensis against Staphycoccus Aureus

作　　者：李仲兴[1] 王秀华[1] 张明明[2] 时东彦[1] 

机构地区：[1]河北医科大学第二医院检验科,石家庄050000 [2]河北省人民医院,石家庄050071

出　　处：《中药新药与临床药理》2005年第2期103-105,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：河北省中医药管理局计划内研究项目(编号2004029)

摘　　要：目的观察五倍子乙醇提取物对金黄色葡萄球菌(MRSA和MSSA)的体外抗菌活性。方法采用中药抑菌实验方法对五倍子乙醇提取物进行了112株金黄色葡萄球菌的最低抑菌浓度测定。结果五倍子乙醇提取物对84株耐甲氧西林的金黄色葡萄球菌(methicillin-resistantstaphylococcusaureus,MRSA)和28株甲氧西林敏感的金黄色葡萄球菌(methicillin-sensitivestaphylococcusaureus,MSSA)的MIC50、MIC90分别为0.315、0.315和0.63、0.315mg/mL。结论五倍子乙醇提取物对金黄色葡萄球菌(84株MRSA和28株MSSA)具有较强的抑菌活性。Objective To evaluate the in- vitro antibacterial activity of e thanol- extract of Galla Chinensis against Staphycoccus aureus (S. aureus).Meth ods The minimum inhibitory concentration (MIC50) of ethanol- extract of Galla Chinensis against 112 strains of S. aureus was detected by using agar dilution method.Results The MIC50 and MIC90 of ethanol- extract of Galla Chinensis aga inst 84 strains of MRSA (methicillin- resistant staphylococcus aureus) were 0. 315, 0.315 mg/mL, and those against 28 strains MSSA (methicillin- sensitive sta phylococcus aureus) were 0.63 and 0.315 mg/mL respectively.Conclusion Ethanol - extract of Galla Chinensis has a strong antibacterial activity against S.aure us.

关 键 词：五倍子 乙醇提取物 耐甲氧西林金葡菌(MRSA) 甲氧西林敏感金葡菌(MSSA) 体外抗菌活性 

分 类 号：R285.5[医药卫生—中药学]