肺炎衣原体感染与急性冠脉综合征的相关性  

The Clinical Study of the Correlation between Chlamydia Pneumoniae Infection and Acute Coronary Syndrome

作　　者：李涛[1] 许香广[1] 蔡俊明 钟跃青[1] 周志玉[1] 张明 张国良[1] 张旭 

机构地区：[1]广东医学院附属深圳福田医院心内科,广东深圳518033 [2]深圳坪山人民医院心内科 [3]亚能生物技术(深圳)有限公司

出　　处：《中国误诊学杂志》2005年第1期4-7,共4页Chinese Journal of Misdiagnostics

基　　金：广东省医学科研基金项目 (编号 :A2 0 0 3731 )

摘　　要：目的 :测定急性冠脉综合征 (ACS)患者阿奇霉素治疗前后血肺炎衣原体 (Cpn) DNA及 Ig G抗体滴度 ,探讨肺炎衣原体感染与 ACS发生的相关关系。方法 :选择 ACS95例 (观察组 )及冠状动脉造影正常的 5 5例非冠心病 (对照组 )。观察组采用随机双盲安慰剂对照的方法分别给予阿奇霉素及安慰剂治疗 6个月 ,治疗前后应用巢式 PCR法测定外周血单核细胞中 Cpn- DNA,用间接微量免疫荧光法测定 Ig G抗体滴度。结果 :Cpn- DNA阳性率及 Ig G抗体滴度观察组较对照组比较阳性率明显增高。治疗后 DNA转阴率阿奇霉素治疗组明显优于安慰剂组 ,Ig G抗体滴度治疗后无明显变化。结论 :ACS患者肺炎衣原体感染率高 ,检测 DNA临床价值更大。Objective:To investigate the correlation between infection with chlamydia pneumoniae(Cpn )and acute coronary syndrome(ACS).Methods:The peripheral blood mononuclear cell(PBMC) Cpn DNA and the titre of chlamydia pneumoniae specific IgG antibodies were measured in 95 patients with ACS and 55 patients without coronary heart disease.Then a prospective,randomized,double-blind, placebo-controlled study was conducted for 6 months in which azithromycin and placebo treatment were adopted respectively in ACS group. After treatment the blood sample were collected for repeated measurement.Results:The positive rates of Cpn DNA and the titres of IgG antibodies in ACS groups were significantly higher than those in control group. There was significiant difference in Cpn DNA negative rates between the azithromycin and the placebo treatment. IgG titre showed no significant difference after treatment either in patients with azithrornycin or in placebo groups.Conclusion:The detection of Cpn DNA in PBMC with nPCR should be of great value for identifying Cpn carriers and for monitoring antichlamydial therapy.

关 键 词：冠状动脉疾病 衣原体 肺炎 衣原体科感染/药物疗法 DNA 细菌/分析 免疫球蛋白G/免疫学 叠氮红霉素/治疗应用 

分 类 号：R541.403[医药卫生—心血管疾病]