水中微量毒鼠强的GC/MS/MS测定法  

Study on the determination of tetrame thylendisulfotetramin in water by GC/MS/MS

作　　者：符展明[1] 金永高[1] 杨勇 符超 

机构地区：[1]宁波市疾病预防控制中心,浙江宁波315010 [2]宁波市自来水公司,浙江宁波315040

出　　处：《中国卫生检验杂志》2005年第3期302-303,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:本文研究应用GC/MS/MS法(气相色谱/质谱检测法)测定水中微量毒鼠强.方法:用苯萃取,过无水硫酸钠柱脱水、活性炭脱色净化,GC/MS/MS法测定.结果:本方法的精密度变异系数(CV)为 3.9%～5.4%,平均回收率为 92.0%～94.8%,最低检测限为 1.0 ng / L.结论:本法操作方便、灵敏度高、准确性好,不但能快速准确检定水中微量毒鼠强的要求,而且能满足中毒患者血液、尿液、胃液样品中的痕量毒鼠强.Objective:To study the method and condition for detection of tetrame thylendisulfotetramin in water by GC/MS/MS.Methods:All samples were purified by benzene,anhydrous sodium sulfate,active carbon,and then analyzed by GC/MS/MS.Results:The detection limit was 1.0 pg/kg,coefficient of variation was 3.9%~5.4%,the rate of recovery was 9.2%~94.8%.Conclusion:The method was sensitive,selective,repeatable and accurate. [

关 键 词：毒鼠强 GC/MS/MS法 中毒患者 胃液 尿液 血液 研究应用 微量 无水硫酸钠 测定法 

分 类 号：R446[医药卫生—诊断学] R595.4[医药卫生—临床医学]