精原干细胞更新分化的影响因素  

Factors Affecting Renewal and Differentiation of Spermatogonial Stem Cells

作　　者：李莲军[1] 卢晟盛[2] 黎宗强[2] 杨小淦[2] 卢克焕[2] 

机构地区：[1]云南农业大学动物科学技术学院,云南昆明650201 [2]广西大学动物繁殖研究所,广西南宁530005

出　　处：《云南农业大学学报》2005年第1期77-82,共6页Journal of Yunnan Agricultural University

基　　金：云南省自然科学基金(2003C0046M);广西科学基金(桂科自0339005)。

摘　　要：精原干细胞可以体外培养、冷冻保存、遗传操作及移植,因而在医学、生物学及动物科学方面均有广泛应用前景。根据现有资料阐述一些因素,包括c Kit受体及其配体SCF、白血病抑制因子(LIF)、维生素A(VA)、表皮生长因子(EGF)、胶质细胞源神经营养因子(GDNF)、激素和温度,对精原干细胞更新分化的影响。Spermatogonial stem cells can be cultured in vitro, cryopreserved, manipulated geneticly, and transplanted. They show a great perspective in biological science, medicine and animal science. The article focuses on some factors and their effects on renewal and differentiation of spermatogonial stem cells, including c-kit receptor and its ligand (stem cell factor), leukaemia inhibitory factor, vitamin A, epithelial growth factor, glial cell line-derived neurotrophic factor, hormone and temperature.

关 键 词：精原干细胞 干细胞因子 白血病抑制因子 VA 表皮生长因子 胶质细胞源神经营养因子 

分 类 号：Q954.43[生物学—动物学] R321.1[医药卫生—人体解剖和组织胚胎学]