Preparation and Acute Toxicology of Nano-Magnetic Ferrofluid  

作　　者：夏泽锋 王国斌 陶凯雄 李剑星 田源 

机构地区：[1]Laparoscopy Centre, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China [2]Department of Biomedical Engineering, Tongji Medical College, Wuhan 430030, China

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2005年第1期59-61,共3页华中科技大学学报（医学英德文版）

基　　金：This project was supported by a grant from the"863"Hi tech Research and Development Program of China ( No.2001AA218051) .

摘　　要：The nano-magnetic ferrofluid was prepared by chemical coprecipitation and its acute toxicology was investigated. The effective diameter (Eff. Diam.) of the magnetic particles was about 19.9 nm, and the concentration of the ferrofluid was 17.54 mg/ml. The acute toxic reaction and the main viscera pathological morphology of mice were evaluated after oral, intravenous and intraperitoneal administration of the nano-magnetic ferrofluid of different doses respectively. Half lethal dose (LD 50)>2104.8 mg/kg,maximum non-effect dose (ED 0)=320.10mg/kg with oral; LD 50>438.50 mg/kg, ED 0=160.05 mg/kg with intravenous route; and LD 50>1578.6 mg/kg, ED 0=320.10 mg/kg with intraperitoneal administration. Degeneration and necrosis of viscera were not found. So the nano-magnetic ferrofluid, of which toxicity is very low, may be used as a drug carrier.The nano-magnetic ferrofluid was prepared by chemical coprecipitation and its acute toxicology was investigated. The effective diameter (Eff. Diam.) of the magnetic particles was about 19.9 nm, and the concentration of the ferrofluid was 17.54 mg/ml. The acute toxic reaction and the main viscera pathological morphology of mice were evaluated after oral, intravenous and intraperitoneal administration of the nano-magnetic ferrofluid of different doses respectively. Half lethal dose (LD 50)>2104.8 mg/kg,maximum non-effect dose (ED 0)=320.10mg/kg with oral; LD 50>438.50 mg/kg, ED 0=160.05 mg/kg with intravenous route; and LD 50>1578.6 mg/kg, ED 0=320.10 mg/kg with intraperitoneal administration. Degeneration and necrosis of viscera were not found. So the nano-magnetic ferrofluid, of which toxicity is very low, may be used as a drug carrier.

关 键 词：nano-magnetic ferrofluid PREPARATION acute toxicity drug carrier 

分 类 号：R595[医药卫生—内科学] R99[医药卫生—临床医学]