我院184例药品不良反应回顾性分析  

Retrospective Analysis of 184 Adverse Drug Reactions Cases

作　　者：杨君[1] 黄仲义[1] 

机构地区：[1]上海市静安区中心医院临床药学和临床药理部,上海市200040

出　　处：《中国药房》2005年第6期455-457,共3页China Pharmacy

摘　　要：目的 :了解我院药品不良反应 (ADR )发生及引发的相关因素。方法 :采用描述性研究方法对1999年4月～2004年7月我院184例ADR报告进行分类统计分析。结果 :184例ADR中 ,女性多于男性 ,男女之比为1∶1.4 ;>60a以上老年人有122例 ,占66.30 % ;单一用药123例 ,合并用药61例 ;ADR程度重度23例 ,中度128例 ,轻度33例 ;对症治疗153例 ,未进行特殊处理31例 ;治愈161例 ,好转17例 ,有后遗症6例 ;因果关系评定为肯定3例 ,很可能153例 ,可能28例 ;抗感染药物引起的ADR占64.39 % ;其次为中枢神经系统药和中药制剂 ,分别占12.33 %、10.05 % ;皮肤及附件损害最多 ,占67.55 %。结论 :应加强ADR的监测和ADR知识的宣传 ,避免或减少其重复发生。OBJECTIVE:To analyze the related factors that initiating the occurrence of adverse drug reactions (ADR). METHODS: The 184 ADR reports occurred from April, 1999 to July, 2004 were analyzed by a descriptive research method. RESULTS: Among the 184 cases, female cases outnumbered the male cases with the ratio at M∶F=1∶1.4, 122 cases were the elderly at the age of more than 60 which accounts for 66.30% of the total;there were 123 single medication cases and 61 combined medication cases;there were 23 severe cases, 128 moderate cases and 33 mild cases; 153 patients were symptomatically treated, 31 cased were not given special treatment;161 patients were fully recovered, 17 cases showed some improvement and 6 cases did have sequela;in the cause-effect relationship assessment, there were 3 certain cases, 153 probable cases and 28 possible cases; the anti-infective-led ADR accounted for 64.39%, then came the central nervous system drugs and Chinese traditional medicines at a percentage of 12.33% and 10.55% respectively;skin and its appendages impairment cases were the most with a percentage at 67.55%.CONCLUSION: To lessen or avoid the occurrence of ADR, monitoring of which and publicizing of ADR knowledge should be emphasized.

关 键 词：药品不良反应 回顾 分析 

分 类 号：R969[医药卫生—药理学]