氯霉素耳用滴丸的制备工艺研究  

Study on preparation of chloramphenicol otic drop pills

作　　者：苏春梅[1] 梁翠茵[1] 张念[1] 杨红[1] 李琳[1] 

机构地区：[1]首都医科大学顺义校区,北京101300

出　　处：《安徽医药》2005年第3期167-169,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的以水溶性高分子材料PEG-6000为基质,研究氯霉素耳用滴丸的最佳制备工艺.方法通过对氯霉素耳用滴丸制备过程的实验,以滴丸的成型,圆整度,重量差异为筛选指标,以药液的保温温度、滴制速度、药物与基质的最佳配比为主要考察因素,对氯霉素耳用滴丸的制备工艺进行优选.并讨论了影响滴丸成型,圆整度及丸重差异的其他因素.结果药物与基质的最佳配比为1:3、药液温度为80～90℃、滴制速度为50滴/分,为最佳制备工艺条件.按照此优化条件制备的氯霉素耳用滴丸成型率最高.结论此制备工艺设备简单,操作方便,不仅适合于氯霉素耳用滴丸的制备,也同样适合于其他滴丸产品的实验室制备及工业化生产.Aim To study the technological parameters of the chloramphenicol otic drop pills in using the PEG6000 as matrics. Methods The process was studied by a series of tests with the formations,the round and the weight deviation of otic drop pills as the cvaluation quota to decide the best dropping condition, and the three factors were the temperature of mixture, the dropping speed of drop pills and the formulation ingredients .The formation and rounduess of pills as well as their weight deviation are discussed. Results The results showed that in order to get the highest moulding probability of the Chloramphenicol otic drop pills, the optimal process was that the Chloramphenicol otic drop pills should be dropped into the mixture of 80～90℃ by 50 dropping per minute with the formulation ingredients of 1 ∶3. Conclusions This preparation method is simple,convenient and can be controlled easily. It is suitable for both the laboratory test and industrial production.

关 键 词：滴丸 氯霉素 制备工艺 药物 圆整度 药液 重量差异 成型 最佳配比 水溶性高分子 

分 类 号：TQ463[化学工程—制药化工]