用人绝经期尿促性腺激素治疗无排卵性不孕症110例分析  

The treatment of anovulation in infertile women with domestic human menopausal gonadotrophin

作　　者：邵敬於 於元笛 陈萍 凌梅立 李善国 冯缵冲[1] 林金芳[1] 周剑萍[1] 于传鑫[1] 李红 周爱平 胡象莲[1] 鲁厚长[1] 

机构地区：[1]上海第一妇婴保健院,上海市计划生育科研所,上海医科大学妇产科医院,中山医院,中国福利会国际和平妇幼保健院

出　　处：《现代妇产科进展》1994年第1期10-14,共5页Progress in Obstetrics and Gynecology

摘　　要：１９９０年１１月至１９９２年３月上海四家医院用国产人绝经期尿促性腺激素（ｈＭＧ）治疗无排卵性不孕症１１０例。患者平均３１．２岁，平均闭经时间５．９年，原发不孕症者占７９％。用ｈＭＧ－ｈＣＧ序贯法治疗１９８个周期，平均每个周期用药３３针。结果：１００例排卵率１００％，周期排卵率９４％，妊娠率５０％，周期妊娠率２７％。卵巢过度刺激综合征发生率３４．３％（轻度１０．９％，中度１９％，重度４．５％），双胎发生率１４．５％。表明国产ｈＭＧ对低促性腺激素性团经和无排卵性稀发月经的治疗效果令人满意。Domestic Human Menopausal Gonadotrophin(hMG) was used in 110 cases in 4 hospitals in Shanghai from November 1990 to March 1992. Patient's PRL levels were normal and FSH, LH levels were low.The incidence of primary infertility was 79%. Sequential regimen with hMG and hCG were used from 6th day of the menstrual cycle with a total of 198 treatment cycles.The results showed that the ovulation rate per case was 100% and per cycle was 94%;the pregnant rate per case was 50%and per cycle was 27%.The complication of ovarian hyperstimulation syndrome(OHHS)was encountered in 38 cases (34.5%)(mild 10.9%; moderate 19% and severe 4. 5%).There were 8 twin pregnancies(14.5%).From the above results, domestic hMG showed satisfactory efficacy in treatment of hypogonadotropic amenorrhea or anovulatory oligomenorrhea.

关 键 词：不育症 女性 闭经 促性腺激素 HMG 

分 类 号：R711.605[医药卫生—妇产科学]