静脉注射微粒对家兔血浆TXA_2、PGI_2及肺动脉压力影响的研究  

Effect of intravenous injection of particles on TXA_2, PGI_2 and pulmonary arterial pressure

作　　者：杨丽丽[1] 涂文婷[1] 王良兴[1] 张旭[1] 张琴辉[2] 范小芳[2] 徐正介[2] 

机构地区：[1]温州医学院附属一院,325000 [2]温州医学院

出　　处：《中华急诊医学杂志》2005年第3期260-262,共3页Chinese Journal of Emergency Medicine

基　　金：浙江省教育厅课题 ( 2 0 0 2 0 44 5 )

摘　　要：目的　研究输液微粒对家兔血浆TXA2和 6 酮基 PGF1a及肺动脉压的影响。方法　取 2 4只家兔随机分为A、B、C三组 ,将三种含不同微粒数的溶液 ,即临床常用的静脉推注药液、同种药液经 10 μm孔径滤过和经 3μm孔径滤过的药液 ,分别注入三组家兔体内 ,并在推注前、推注后即刻、 30min、 6 0min、 30 0min五个时间点检测血浆TXA2 和PGI2 的代谢物TXB2 和 6 酮基 PGF1a的浓度 ,并进行肺动脉压监测 ,观察注射微粒对其影响。结果　TXB2 的浓度随着 5个不同的时间点时间推移均呈逐渐升高。其中A组在推注后 6 0min时的浓度与未推注前比较有显著意义 (P <0 0 5 ) ,推注后 30 0min比较有明显差异 (P <0 0 1) ;B组在推注后 6 0min和 30 0min的浓度与未推注前比较有显著意义 (P <0 0 5 )。血浆 6 酮基 PGF1a的浓度变化显示 :A组中第2、 3两个时间点的浓度与未注时比较有显著意义 (P <0 0 5 )。肺动脉压力变化呈现先高后低现象。结论　为病人推注高浓度药物时 ,应用有效的终端过滤器进行截拦后推注较安全 。Objective To study the effect of intravenous injection of particles on thromboxane (TX) A 2 and prostaglandin(PG)I 2 level in plasma and pulmonary arterial pressure of rabbits.Methods 24 rabbits were randomly divided into group A, group B, and group C. Each group was injected with physic liquors containing different numbers of particles. Before the injection, physic liquors were filtrated by filters with 10um diameter and 3um diamater. TXA 2 and PGI2's metabolin-Thromboxane (TX) B 2 and 6-keto-prostacyclin F 1a before injection, 0 minutes, 30 minutes, 60 minutes and 300 minutes after injection.Results TXB 2 level increased with the time going on. Compared with before injection in group A and group B, TX B 2 level at 60 minutes and 300 minutes showed significant difference (P<0.05). (2) Compared with before injection in group A, 6-keto-prostacyclin F 1a at 0 minutes and 30 minutes after injection showed significant difference (P<0.01). (3) Pulmonary arterial pressure increased first and then reduced.Conclusion It's safer that high-level physic liquors are filtrated by effective terminal filters before intravenously injection. We should be cautious when injecting intravenously to patients with pulmonary hypertension or pulmonary dysfunction.

关 键 词：血浆 TXA2 PGI2 肺动脉压力 静脉推注 家兔 TXB2 浓度 粒数 药液 

分 类 号：R472[医药卫生—护理学]