糖皮质激素治疗慢性特发性血小板减少性紫癜疗效相关因素分析  

Analysis on related factors influencing the efficacy of glucorticoid in treating chronic idiopathic thrombocytopenic purpura

作　　者：程洪波[1] 罗敏智[1] 张胜敏[1] 王晓莉[1] 

机构地区：[1]江西省人民医院血液科,南昌330006

出　　处：《临床血液学杂志》2005年第2期87-88,共2页Journal of Clinical Hematology

摘　　要：目的:探讨影响糖皮质激素治疗慢性特发性血小板减少性紫癜疗效的有关因素。方法:采用Logistic回归对74例经糖皮质激素治疗的慢性特发性血小板减少性紫癜患者性别、年龄、是否并发除皮肤出血以外较严重的出血表现、起病至开始治疗时间、是否有脾脏肿大、是否并发肝炎病毒感染、治疗前血小板计数、骨髓巨核细胞数8项因素进行多因素分析。结果:起病至开始治疗时间,是否并发肝炎病毒感染,骨髓巨核细胞数是影响糖皮质激素治疗慢性特发性血小板减少性紫癜疗效的相关因素。结论:分析患者治疗前各项可能影响疗效的相关因素,对于指导慢性特发性血小板减少性紫癜治疗方案的选择,尤其是合理掌握糖皮质激素的使用时间有重要意义。Objective:To study the factors influencing the efficacy of glucorticoid in treating chronic idiopathic thrombocytopenic purpura.Method:Factors(sex, age, clinical manifestation, course of disease, the size of spleen, hepatitis virus, blood platelet count, bone marrow megakaryocyte) were analyzed by binary Logistic Regression with SPSS 10.0.Result:course of disease, hepatitis virus, bone marrow megakaryocyte are the factors influencing the efficacy of glucorticoid in treating chronic idiopathic thrombocytopenic purpura.Conclusion:Analysing these factors influencing the efficacy of glucorticoid in treating chronic idiopathic thrombocytopeuic purpura is important for reasonable use of glucorticoid.

关 键 词：紫癜 血小板减少性 糖皮质激素 预后 

分 类 号：R554[医药卫生—血液循环系统疾病]