茯苓抗诱变效应的实验研究  

Experiment Research of Antimutagenesis Effect from Pria Cocos Wolf

作　　者：赵景春[1] 

机构地区：[1]北京教育学院生化环境系,北京100011

出　　处：《北京教育学院学报》2004年第4期58-59,共2页Journal of Beijing Institute of Education

摘　　要：采用姊妹染色单体交换(SCE)和骨髓嗜多染红细胞微核(MN)方法对中药茯苓进行抗诱变细胞学实验研究.评价了茯苓对诱变剂苯并[a]芘(B[a]P)诱发小鼠遗传损伤的拮抗作用.实验表明,茯苓的抗诱变效应是明显的(P<0.01).对SCE的抑止率为37.4%,MN的抑止率为46.7%.本文还对其拮抗机制进行了阐述.提出了茯苓多糖的防护意义.By using sister chromatidexchange (SCE) ,micronucleus(MN) and Ames text as indexes, the protective effect of Pria cocos Wolf on genetic damageInduced by BP was studied in Kunming mice strain. Results showed that the Chinese medicines can significantly decrease SCE and MN frequencies induced by BP. Results were distict ( P<0.01 ). The peper indicated that the Pria cocos Wolf had obvious antimutagenesis potentials.

关 键 词：茯苓 姊妹染色单体交换 微核 抗诱变 

分 类 号：Q355[生物学—遗传学]