TP和ASA对老年常见血栓性疾病的影响  

Different Effects of TP and ASA on the Aged Patients with Common Thrombotic Disordes

作　　者：郑杭玲[1,2,3] 金宏义[1,2,3] 庄作民[1,2,3] 谢海宝[1,2,3] 林兵 贺小慰[1,2,3] 张忠林 

机构地区：[1]浙江医院心内科 [2]浙江省人民医院神经科 [3]浙江省老年医学研究所

出　　处：《现代应用药学》1994年第5期27-28,共2页

摘　　要：对８０例老年血栓性疾病非急性梗塞期患者随机应用ＴＰ或ＡＳＡ，结果表明，在延长出血时间、抑制０．５μｍｏｌ，２．０μｍｏｌＡＤＰ诱导的血小板Ｐｔｍａｘ、抑制ＡＴ－Ⅲ活性及降低纤维蛋自原含量方面，ＴＰ的作用优于ＡＳＡ．在抑制２．７８μｍｏｌ，５．５６μｍｏｌＡｄｒ诱导的血小板Ｐｔｍａｘ和降低全血还原粘度方面，两者相近。In this randomized study, patients received either TP 250 mg (n =44, M31, F13, 69 .7 6.1y) or 162.5 mg (n = 36, M29, F7, 70.4 5.9 y ) a dayx 30d. The results showed that theinhibition of platelet aggregation rate induced by ADP of TP was much more potent than thatof ASA, The TP pro1Onged bleeding time and significantly reduced fibrinogen levels. The inhi-bition of platelet aggregation rate induced by Adr and the whole blood returning viscosityreduced were similar for both groups.

关 键 词：抵克力得 阿斯匹林 血栓性疾病 血小板聚集 

分 类 号：R973.2[医药卫生—药品]