正常妊娠妇女卵泡休止素水平的变化及其临床意义  

Changes and significance of serum follistatin in women with normal late pregnancy

作　　者：侯文静 尚涛[2] 秦英 郑桂玲 

机构地区：[1]辽宁省本溪市中心医院妇产科 [2]中国医科大学附属第二医院妇产科,辽宁沈阳110004 [3]辽宁省东港市妇幼保健院 [4]辽宁省本溪市妇幼保健院

出　　处：《中国医科大学学报》2005年第1期78-79,共2页Journal of China Medical University

摘　　要：目的:探讨正常妊娠妇女卵泡休止素(FS)水平变化及其临床意义。方法: 采用FS双抗体酶联免疫吸附法(ELISA)测定 210例妊娠晚期妇女的血清FS水平,同时测定 51例妊娠晚期妇女血清中游离雌三醇 (FE3)的水平,并分析其与FS的关系。结果: 血清中FS浓度随着孕周的增加而升高,与孕周呈正相关。建立正常妊娠晚期每相邻两周血清FS参考值。妊娠晚期FS水平变化与FE3水平变化呈正相关。结论: FS可作为估计孕周、判定胎儿-胎盘单位功能的一项生化指标。Objective: To study the changes of concentrations of follstatin (FS) in women with normal late pregnancy. Methods: The FS was determined by using sandwich enzymelinked immunoabsorbent assay (ELISA) in 210 women. We also determined the free estriol (FE3) levels in 51 women, and analyzed the possible correlation between levels of FS and FE3. Results: The serum FS increased with the advance of pregnancy. There was a strongly positive correlation between serum FS and gestational weeks (r=0.864, P<0.001). We established the reference value of FS between every 2 weeks in the late gestation. Level of FS was positively correlated with level of FE3. Conclusion: The FS can be used as a biochemical index for estimating gestational weeks and evaluate feto-placental unit function.

关 键 词：卵泡休止素 正常妊娠 孕周 胎儿-胎盘单位 

分 类 号：R711[医药卫生—妇产科学]