温石棉纤维对AM毒作用与其分散度的关系  

AN IN VITRO STUDY OF THE DISTRIBUTION OF CHRYSOTILE FIBERS AND ITS EFFECTS ON AM

作　　者：张建新[1] 梁娴[1] 姚群梅 柯佛心[1] 

机构地区：[1]华西医科大学尘肺研究室,成都市卫生防疫站,南省楚雄州医院

出　　处：《现代预防医学》1994年第2期73-76,共4页Modern Preventive Medicine

摘　　要：通过体外细胞培养的方法，观察到不同分散度的新康温石棉纤维（Ａ，Ｂ和Ｃ三种纤维长径小于２０μｍ分别为２７％，３６％和９５％）对免肺泡巨噬细胞（ＡＭ）的毒性作用不同，可致ＡＭ存活率降低，ＡＭ吞噬能力降低和致乳酸脱氢酶（ＬＤＨ）溢漏增加，以分散度最高的石棉纤维Ｃ作用最强，纤维Ｂ次之，分散度最低的纤维Ａ作用最弱。结果表明温石棉纤维对ＡＭ的细胞毒作用与其分散度有关，与其表面积大小有关。The results of this in vitro study showed that the chrysotile fibers with different distribution (A, B and C with 27%, 36% and 95% fibers length shorter than 20 μm respectively) have different potential of damaging rabbit alveolar macrophages (AM) by decreasing the survival rate and the phagocytic ability of AM and increasing the release of lactate dehydrogenasc (LDH), the fiber C with highest distribution showed the strongest effects on AM, next is fiber B and the weakest one is fiber A. From the results it can be concluded that the relationship between the cytotoxic effects of chrysotile fibers and its distribution is certain and this may be related with its surface areas.

关 键 词：温石棉 肺泡巨噬细胞 粉尘 

分 类 号：R135.2[医药卫生—劳动卫生]