尿毒症顽固性高血压的治疗研究  

Study on the treatment of refractory hypertension caused by uremia

作　　者：游天禄[1] 何娅妮[2] 游小丽[3] 

机构地区：[1]第三军医大学成都军医学院47医院内一科,四川新都610500 [2]第三军医大学大坪医院肾内科,重庆400042 [3]成都市新都区人民医院内一科,四川成都610500

出　　处：《西南国防医药》2004年第3期243-245,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的 :探讨治疗尿毒症顽固性高血压的有效方法。方法 :30例尿毒症顽固性高血压病患者被分为 3组 ,1组服用缬沙坦 +卡托普利缓释片 (联合组 ) ,2组服用缬沙坦 (缬沙坦组 ) ,3组服用卡托普利缓释片 (缓释片组 )。实验前3组均服用硝苯地平、倍他乐克。比较各组治疗 4周前后早晨 6点血压、血浆内皮素水平以及超声心动图的变化。结果 :治疗后 3组早晨 6点血压、血浆内皮素水平及E/A值较治疗前均有显著下降 (P <0 0 1) ,其中联合组较缓释片组和缬沙坦组更显著 (P <0 0 1)。结论 :缬沙坦、卡托普利缓释片是治疗高血压的有效药物 ,二者联合应用是治疗尿毒症顽固性高血压的较好方法。Objective:To explore an effective therapeutic way for refractory hypertension caused by uremia.Methods:Thirty patients with refractory hypertension caused by uremia were divided randomly into 3 groups:combination group,in which the patients were given valsartan and captoril sustained-release tablets;valsartan group,in which the patients were given only valsartan;and captoril group,in which the patients were given only captoril.All the 30 patients were given nifedipine and betaloc before experiment.We compared the blood pressure at 6∶00 am,level of plasma ET-1 and changes of ultrasonic cardiogram 4 weeks before and after treatment.Results:After treatment,the blood pressure at 6∶00 am,level of plasma ET-1 and E/A value all decreased significantly in the three groups(P<0.01)but those changes in combination group were most obvious(P<0.01)。Conclusion:Both valsartan and captoril sustained-release tablets are effective in the treatment of hypertension and the combined use of them is a comparatively more effective way for refractory hypertension caused by uremia.

关 键 词：尿毒症 难治性 高血压 肾脏 

分 类 号：R691[医药卫生—泌尿科学]