慢性肺心病二氧化碳潴留与低氯血症相关性分析  

Study on correlative analysis of carbon dioxide retention and hypochloraemia in chronic cardiopulmonary disease

作　　者：王蓉美[1] 张小瑜[2] 罗先蓉[2] 周健[2] 

机构地区：[1]北京空军总医院呼吸内科,北京100036 [2]解放军第452医院内二科,四川成都610021

出　　处：《西南国防医药》2004年第3期250-251,共2页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的 :探讨慢性肺心病二氧化碳潴留与低氯血症的相关关系。方法 :同步检测 5 3例慢性肺心病急性发作期患者动脉血气和电解质。以PaCO2 ≥ 7.3kPa为界 ,分为CO2 潴留组和非CO2 潴留组 ,两组指标统计学处理 ,分析血氯与PaCO2 的相关性。结果 :CO2 潴留组发生低氯血症 74 1% (2 0 / 2 7) ,非CO2 潴留组低氯血症 4 2 3% (11/ 2 6 ) ,两组血氯、PaCO2 、HCO-3 比较有统计学差异 ,且血Cl-与PaCO2 呈显著负相关 (r=- 0 4 0 5 ,P <0 0 5 )。结论 :肺心病急性加重期的电解质紊乱常表现为低氯血症 ,并与PaCO2 呈显著负相关。治疗中及时补氯 ,不仅可纠正低氯血症 ,而且可以加速HCO-3 /Cl-交换 ,有助于CO2 排出。objective: To explore the correlation between carbon dioxide (CO 2) retention and hypochloremia in chronic cardiopulmonary disease. Methods: We detected 53 patients' arterial blood gas and electrolyte in acute episode of chronic cardiopulmonary disease. The patients were divided into CO 2 retention group and no CO 2 retention group with PaCO 2>7.3kpa as the limitation. Statistical analysis was employed to analyze the correlation between chlorine and PaCO 2.Results: Hypochloremia accounted for 74.19(20/27) and 43.39(11/26) in CO 2 retention group and no CO 2 retention group, respectively. There were statistical differences in blood chlorine, PaCO 2, HCO3 between the two groups. What's more, significant negative correlation was observed between blood chlorine and PaCO 2(r=-0.405,p<0.05). Conclusion: Electrolyte disturbance is commomly manifested as hypochloremia in acute exacerbation phase of chronic cardiopulmonary disease and it has significant negative correlation with PaCO 2. In-time chlorine supplement in the treatment not only can redress hypochloremia but also can accelerate the exchange of HCO - 3 /Cl- , which can contribute to the ejection of CO 2.

关 键 词：慢性肺心病 二氧化碳潴留 低氯血症 

分 类 号：R541[医药卫生—心血管疾病]