大鼠全腹照射后血中NO及iNOS含量的变化  

Changes of serum NO/iNOS after whole abdominal irradiation in rats

作　　者：林红[1] 吴薇[1] 张焜和[1] 陈江[1] 汪泱[1] 罗辉[1] 黄小青[1] 

机构地区：[1]江西医学院第一附属医院,南昌330006

出　　处：《中华放射医学与防护杂志》2004年第6期536-537,共2页Chinese Journal of Radiological Medicine and Protection

基　　金：江西省科委Ⅱ级基金资助项目 (F970 5 0 6)

摘　　要：目的　观察大鼠全腹照射后血清一氧化氮 (NO)及诱导型一氧化氮合酶 (iNOS)水平的变化及其与放射性肠道损伤的关系。方法　将 30只SD大鼠随机分为正常对照组、照射对照组、IgY预防组 ,取血清测定NO及iNOS。结果　照射对照组NO及iNOS水平均明显高于正常对照组 (P <0 0 1) ,是后者的 3倍。IgY预防组NO及iNOS水平均明显低于照射对照组 (P <0 0 1) ,稍高于正常对照组。NO与iNOS升高同步。结论　NO及iNOS能较好地反映放射性肠道损伤。Objective To observe the changes of serum NO/NOS concentrations in rats after whole abdominal irradiation and their relationships with intestinal radiation injury. Methods Thirty health rats were randomly divided into three groups:normal control group,irradiation control group,and IgY protection group.The sera of rats were collected and the NO and iNOS were assayed. Results NO and iNOS levels increased evidently in the irradiation control group in contrast with those of the normal control group (P<0.01).NO and iNOS levels increased slightly in the IgY protection group in contrast with the irradiation control group(P<0.01) and were close to the levels of the normal control group.The changes of NO and NOS concentrations were synchronous. Conclusion NO and iNOS are good indices for detecting intestinal radiation injury.;

关 键 词：NOS含量 对照组 照射 正常 大鼠 肠道损伤 预防 放射性 水平 随机 

分 类 号：R818[医药卫生—放射医学]