止咳平喘胶囊质量标准研究  

Quality standard of Zhike Pingchuan Capsules

作　　者：陈萍[1] 朱胤龙[1] 韦强[1] 闫便节[1] 

机构地区：[1]陕西省中医药研究院制剂中心,陕西西安710003

出　　处：《中成药》2005年第3期275-278,共4页Chinese Traditional Patent Medicine

摘　　要：目的建立止咳平喘胶囊(西洋参,杏仁,黄芩,甘草,川贝母等)质量标准。方法用薄层色谱法鉴别西洋参、甘草、川贝母;用高效液相色谱法测定人参皂苷Rb1含量,采用μBondpackC18柱,以乙腈水(34∶66)为流动相,流速1.2mL·min-1,检测波长203nm,柱温40.0℃,灵敏度0.02AUFS。结果人参皂苷Rb1含量在0.612～6.12μg呈良好的线性关系,平均回收率97.20%,RSD为2.25%。结论建立的定性定量方法简便、重复性好,可作为止咳胶囊的质量控制。AIM: To establish the quality standard for Zhike Pingchuan Capsule (Radix Panacis Quinquefolii, Semen Pruni Armeniacae, Radix Scutellariae, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae, etc.). METHODS: Radix Panacis Quinquefolii, Radix Glycyrrhizae, Bulbus Fritillariae Cirrhosae in Zhike Pingchuan Capsule were identified by TLC and ginsenoside Rb_1 was determined by HPLC. The analysis was carried out on C_~18 column by HPLC. The mobile phase was CH_3CN-H_2O(34∶66). The flow rate was 1.2 mL·min^-1 and the detection wavelength was at 203 nm. The column temperature was at 40.0 ℃ and sensitivity was 0.02 AUFS. RESULTS:The average recovery was 97.20% and RSD was 2.25% and the linear range of ginsenoside Rb_1 was in 0.612-~6.120 μg. CONCLUSION:This method is simple, rapid with a good reproducibility. This method can be used for the quality control of Zhike Pingchuan Capsule.

关 键 词：止咳平喘胶囊 人参皂苷RB1 质量标准 

分 类 号：R927.2[医药卫生—药学]