蒿蓝感冒颗粒的质量标准研究  

Quality standard for Haolanganmao Granules

作　　者：刘君康 许馨燕 刘砥威 苏雅莉 陈希元 

机构地区：[1]新疆维吾尔自治区药品检验所,新疆乌鲁木齐830002 [2]新疆维吾尔自治区药物研究所,新疆乌鲁木齐830002

出　　处：《中成药》2005年第3期279-282,共4页Chinese Traditional Patent Medicine

摘　　要：目的建立蒿蓝感冒颗粒的质量标准。方法采用薄层色谱法对板蓝根、一枝蒿进行定性鉴别;并应用高效液相色谱法对其中的对乙酰氨基酚;盐酸伪麻黄碱进行含量测定。结果薄层色谱法均能对板蓝根、一枝蒿进行专属定性分析;对乙酰氨基酚、盐酸伪麻黄碱分别在80μg·mL-1～200μg·mL-1((r=0.9999));20μg·mL-1～120μg·mL-1(r=0.9998)范围内线性关系良好,平均回收率分别为99.7%(RSD=0.89%)和100.1%(RSD=1.1%)。结论所建立的方法可准确地进行定性、定量检测,能排除其他成分干扰,重复性好。可作为该制剂的质量控制和评价。AIM: To establish quality standard for Haolanganmao Granules. METHODS: Herba Achilleae, Radix Isatidis were identified by TLC. The content of paracetamol, pseudoephedrine in the granules were assayed by HPLC. RESULTS: Herba Achilleae, Radix Isatidis could be indetified by TLC. Paracetamol and pseudoephedrine showed a good linear relationship at the range of 80 μg·mL^-1 -200 μg·mL^-1 ( r=0.999 8); and 20 μg·mL^-1 -120 μg·mL^-1 (r=0.999 9), respectively. The recoveries were 99.7% (RSD=0.81%) and ~100.1% (RSD=1.1%), respectively. CONCLUSION: The method is accurate and can be used for the quality control of Haolanganmao Granules.

关 键 词：蒿蓝感冒颗粒 板蓝根 一枝蒿 对乙酰氨基酚 盐酸伪麻黄碱 质量标准 TLC HPLC 

分 类 号：R927.2[医药卫生—药学]