罗非昔布超前镇痛在无痛人流术中的应用  

THE PREEMPTIVE APPLICATION OF ROFECOXIB IN PAINLESS INDUCED ABORTION

作　　者：张立贤[1] 王家双[1] 彭亮[1] 杨庆耿[1] 王爱群[1] 陈剑龄[1] 舒慧芳[2] 

机构地区：[1]广州市红十会医院,南大学医学院第四附属医院麻醉科,广州510220 [2]广州市红十会医院,南大学医学院第四附属医院妇科,广州510220

出　　处：《中国疼痛医学杂志》2005年第1期22-24,共3页Chinese Journal of Pain Medicine

摘　　要：目的 :观察罗非昔布超前镇痛应用于异丙酚无痛人流术的临床效果。方法 :选择ASAⅠ～Ⅱ级、妊娠 5～ 12周拟行人工流产手术患者 80例 ,随机分为PR和P组。PR组患者术前 6小时口服罗非昔布 5 0mg ,术中使用异丙酚静脉麻醉 ;P组单纯应用异丙酚麻醉 ,两组患者异丙酚的诱导量均为 2mg/kg ,术中根据患者的躯体反应必要时追加诱导量的 1/ 3～ 1/ 2。观察用药前后血压、心率、血氧饱和度的变化、宫颈松弛情况、异丙酚用量、清醒时间、追加用药的例数、术中肢动情况及术后患者下腹疼痛程度。结果 :用药前后血压、心率、血氧饱和度的变化、宫颈松弛情况、异丙酚用量、追加用药的例数及清醒时间两组无明显差别 (P >0 .0 5 ) ;PR组患者术后下腹疼痛程度明显低于P组 ,术后 5、10、15分钟时的VAS评分两组比较有显著性差异 (P <0 .0 5 )。结论 :罗非昔布联合异丙酚应用于无痛人流术 ,对异丙酚术中的麻醉效果无明显增强作用 ,但可显著减轻患者术后下腹疼痛程度 ,患者满意度提高。Objective: To evaluate the effect of rofecoxib during painless induced abortion. Methods: Eighty patients undergoing painless abortion were vandomly divided into two groups: PR and P. Group PR received rofecoxib 50mg before operation . Both were given propofol 2mg/kg to induce general anesthesia. Additional dosage of propofol were given 1/3～1/2 of induced dosage according to the condition during operation. Blood pressure, heart rate and SpO 2 were measured. The relaxation of cervix, the total dosage, the time of consciousness ,the cases receiving supplementary propofol and the movement were recorded. Pain intensity of lower abdomen was assessed. Results: There was no difference in blood pressure, heart rate, SpO 2, the relaxation of cervix, the total dosage, the time of consciousness and the cases receiving supplementary propofol between the two groups ( P >0.05). Significantly less lower abdominal pain was found in group PR by VAS at 5, 10, 15 minutes ( P <0.05) after operation. Conclusion: Rofecoxib could significantly relieve postoperative lower abdominal pain, although it didn' t enhance the anesthetic effect of the painless induced abortion with propofol.

关 键 词：罗非昔布 超前镇痛 无痛人流术 临床应用 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]