醋氯芬酸对大鼠的长期毒性试验  

Long-term Toxicity of Aceclofenac in Rats

作　　者：陈四艳[1] 周一平[1] 何立华[1] 陈奇有[1] 杨静华[1] 

机构地区：[1]湖北省医药工业研究院,武汉430061

出　　处：《医药导报》2005年第4期281-282,共2页Herald of Medicine

摘　　要：　目的　考察连续给予醋氯芬酸对大鼠产生毒性反应的剂量。方法　112只Wistar大鼠随机分为 4组,低、中剂量组各 24只分别给予醋氯芬酸 3, 6mg·kg 1·d 1,高剂量组 32只给予醋氯芬酸 12mg·kg 1·d 1,对照组 32只给予相同体积的 0 5%羧甲基纤维素钠(CMC Na) ,各组连续灌胃给药 3个月,进行血液学、血液生化、脏器重量系数、组织病理学检查及常规观察。结果　低、中剂量组大鼠各项指标无明显变化,与对照组比较差异无显著性 (P>0 05)。高剂量组大鼠血清中总胆固醇升高,肝脏系数增加,胃肠道偶发变性坏死,但停药后恢复。结论　醋氯芬酸对大鼠的安全剂量为 6mg·kg 1·d 1,醋氯芬酸 12mg·kg 1·d 1引起的毒性反应是可逆。Objective To probe into the long term toxicity of aceclofenac in rats. Methods 112 Wistar rats were randomly divided into 4 groups. Both the low and medium dose groups consisted of 24 rats .Animals of these 2 groups were given each by gastrogavage 3 and 6 mg·kg 1 ·d 1 of aceclofenac ,respectively. 32 rats of the high dose group were given each in the same way 12 mg·kg 1 ·d 1 of aceclofenac, and 32 rats of the control group were given each equivalent volume of 0.5% CMC Na(sodium carboxymethyl cellulose). The term of treatment in all 4 groups lasted 3 months .Indexes of hematology and blood biochemistry, weight coefficients of organs, histopathology of various organs etc., were subjected to systematic examinations. Results Accidental degeneration and necrosis of the gastrointestinal tract , increased content of serum total cholesterol and increased weight coefficient of the liver were demonstrated in rats treated with aceclofenac in a daily dose of 12 mg·kg 1 . These changes,however, disappeared after the drug administration had been discontinued. Rats treated with the drug in daily doses of 3 and 6 mg·kg 1 showed no significant changes as mentioned above. Conclusion A daily dose of 6 mg·kg 1 of aceclofenac was safe in the rats and the pathological changes resulted from administration of 12 mg·kg 1 ·d 1 of the drug were shown to be resversible.

关 键 词：醋氯芬酸 毒性反应 

分 类 号：R971.1[医药卫生—药品] R965.1[医药卫生—药学]