咪唑并〔1,2-b〕哒嗪  

Imidazo 〔1,2-b〕 Pyridazine

作　　者：付春[1] 

机构地区：[1]中石化南京化工厂研究所,江苏南京210038

出　　处：《精细与专用化学品》2005年第5期14-15,共2页Fine and Specialty Chemicals

摘　　要：介绍了咪唑并〔1, 2- b〕哒嗪的合成方法、用途、生产及需求。以 3, 6- 二氯哒嗪为原料,经氨化、环合、脱氯得咪唑并〔1, 2- b〕哒嗪。咪唑并〔1, 2- b〕哒嗪是合成头孢类抗生素的侧链中间体,因合成难度较大,成为国内开发头孢唑兰的瓶颈。The preparation, application, production and demand of imidazo〔1,2-b〕pyridazine were introduced. Based on 3,6-dichloropyridazine, imidazo〔1,2-b〕pyridazine was synthesized via amination, cyclization and dechlorination. Imidazo〔1,2-b〕pyridazine is the main intermediate with side chain for synthesis of cephalosporins, it has become a bottle-necking problem for development of cefozopran as its greater difficulty in synthesis.

关 键 词：环合 咪唑 合成方法 中间体 头孢类抗生素 侧链 原料 难度 脱氯 氨化 

分 类 号：TQ251[化学工程—有机化工]