老年2型糖尿病患者尿微量白蛋白与C反应蛋白及胰岛素抵抗关系的临床观察  

Clinic study on relation of urine microalbumin with c-reactive protein and insulin resistance in type 2 diabetic elderly patients

作　　者：张淑芳[1] 汪海东[2] 曹春玲[1] 王丽[1] 

机构地区：[1]山东省济南市第一人民医院,山东济南250011 [2]山东省千佛山医院,山东济南250011

出　　处：《中国医学工程》2005年第1期20-21,24,共3页China Medical Engineering

摘　　要：目的了解老年2型糖尿病患者尿白蛋白排泄率(UAER)与C反映蛋白(CRP)及胰岛素抵抗(ISI)的关系。方法对血压正常的42例老年2型糖尿病合并微量白蛋白尿(MAU)患者与36例未合并MAU患者的C反应蛋白、胰岛素敏感指数(ISI)及血糖进行比较分析。并对所有病例的UAER与有关因素进行多因素逐步回归分析。结果老年2型糖尿病合并MAU时,其ISI显著降低(P<0.01)。UAER与.ISI呈独立的相关性[偏回归系数(β)=0.39,P<0.01],而与CRP呈正相关。CRP与ISI呈显著负相关(P<0.01)。结论血压正常的老年2型糖尿病的胰岛素抵抗是MAU的独立危险因素,CRP也是MAU的危险因素。objective To investigate the relationship of urinary albumin excertion rate(uAER), C-reactive protein (CRP) and insulin resistance in type 2 diabetic elder patients. Method Seventy-eight diabetes diabete mellitus typ e=2 patients with nomal blood pressure were divided into two groups:subject grou p (n=42) companied with microalbuminuria(MAU) and control group (n=36) have not any album in urine. Compare their plasma level of CRP, insulin sensitive index(I SI)and blood sugars, and analyse the relationship between uAER and other relevan t factors with logistic regression. Result ISI decreased significantly in di abete mellitus type2 patients who were companied with MAU (P<0.01). ISI and uAER were independent correlative (β=0.39, P<0.01). ISI was negative correlative wi th CRP, butu AER was positive correlative with CRP (P<0.01). Conclusion ISI and CRP are respective independent predictor of MAU in diabete mellitus type2 pa tients.

关 键 词：老年2型糖尿病 CRP 胰岛素抵抗 患者 UAER C反应蛋白 血压正常 多因素 正相关 降低 

分 类 号：R587[医药卫生—内分泌] R541.4[医药卫生—内科学]