阿苯达唑脂质体的包封率测定及形态观察  

Determination on Percentage of Drug Entrappment and Observation of Electron Microscopy in Liposomal Albendazole

作　　者：王建华[1] 温浩[1] 买尔旦[1] 

机构地区：[1]新疆医学院第一附属医院普外科

出　　处：《新疆医学院学报》1994年第1期18-21,共4页

基　　金：欧洲科学技术发展委员会STD-2项目

摘　　要：本文报道采用葡聚糖凝胶过滤法分离阿苯达唑脂质体（简称ＬＡＢＺ）和游离药物的方法，并结合紫外分光光度法测定了药物的包封率，ＬＡＢＺ药物包封率达７６％～８６％；用电子显微镜负染观测了ＬＡＢＺ的形态和平均粒径，电镜图片显示ＬＡＢＺ为多层脂质体，平均粒径分布为０．０３～０．０６μｍ。his paper reported the methed that the percentage of drug en ttapped in liposomal albendazole(LABZ)was detetmined by gel filtration using column of sephadex G-50,and combined with ultravioletspectrophotometer at 295 nm.For three LABZ batches,the percentage of entrappment were 76%～86%.It was showed that LABZ was multilamellar vesicles by negative stain electron microscopy itsaverage diameter distributed among 0.03～ 0. 06μm.

关 键 词：阿苯达唑 脂质体 包封率 形态 

分 类 号：R944[医药卫生—药剂学]