孕甾酮在超临界CO_2中的溶解度测定与模拟  

Determination and simulation of progesterone solubility in supercritical CO_2

作　　者：杨学稳[1] 姚天国[2] 廖晓兰[1] 冯勇刚[1] 黄震[3] 

机构地区：[1]天津城市建设学院材料工程系,天津300384 [2]天津城市建设学院热能工程系,天津300384 [3]新加坡国立大学化工系,新加坡119260

出　　处：《天津城市建设学院学报》2005年第1期48-51,共4页Journal of Tianjin Institute of Urban Construction

摘　　要：　　采用动态法测定孕甾酮(progesterone)在超临界CO2 溶液中的平衡溶解度,所用的压力范围为12~24MPa,温度为313. 15K和323. 15K, 结果表明其摩尔分数为5. 3×10-5 ~8. 9×10-4.实验数据经Chrastil密度型模型和Peng Robinson状态方程模拟, 均取得较好的吻合, 前者归纳出孕甾酮溶解度与CO2 密度之间的关系式lny2 = -73. 56 +8. 56·lnρ-5 733.08/T, 后者可利用所得到的结果预测孕甾酮在其它条件下的溶解度.The equilibrium solubility of progesterone in the supercritical CO_2 solution was measured by using a dynamic method at pressures between 12 MPa and 24 MPa, at temperatures of 313.15 K and 323.15 K. The result shows that the molar fraction of progesterone solubility is in the range of 5.3×10^(-5)~8.9×10^(-4). And the experimental data well correlated with the empirical density-based Chrastil model and the Peng-Robinson equation of state model. The former generalizes the relationship between the progesterone solubility and supercritical CO_2 density:ln y_2=-73.56+8.56·ln ρ-(5 733.08/T.) The later along with modeled results can be use to further predict the progesterone solubility at other conditions.

关 键 词：孕甾酮 超临界CO22溶液 溶解度测定 Chrastil模型 Peng—Robinson状态方程 

分 类 号：TQ460[化学工程—制药化工]