桥本甲状腺炎合并甲状腺癌的临床病理研究  

A clinicopathological study on the Hashimoto's thyroiditis in combination with papillary thyroid carcinoma

作　　者：杨践[1] 何永刚[2] 蔡伟耀[2] 李宏为[2] 

机构地区：[1]上海中医药大学附属曙光医院病理科,上海200021 [2]上海第二医科大学附属瑞金医院外科,上海200025

出　　处：《诊断学理论与实践》2005年第1期12-16,共5页Journal of Diagnostics Concepts & Practice

摘　　要：目的:探讨桥本甲状腺炎(HT)与甲状腺乳头状癌(PTC)的关系。方法:单纯HT73例,HT合并PTC23例,分析两者的临床表现、病理组织学表现,并作酪氨酸激酶受体(RET)免疫组化染色。结果:HT临床表现多样化,部分表现为结节状,合并的甲状腺癌均为乳头状癌,且微小癌占多数。50%HT病变对于RET染色存在局灶性阳性反应。结论:HT病变组织中不同程度地存在与PTC相同的肿瘤基因,HT合并的PTC可能与HT有关。Objective To study the relationship between the Hashimoto's thyroiditis (HT) and the papillary thyroid carcinoma (PTC). Methods Seventy-seven cases with HT were studied, among whom 23 had PTC simultaneously. The clinical and pathological manifestation and RET immunohistochemical assay were carried out. Results The clinical re-presentations of HT were diverse, part of which were associated with nodules. The concomitant thyroid carcinoma was PTC, most of which in HT was the early tumor. Fifty percent of HT showed the focal positive expression under RET staining. Conclusions There exists the PTC oncogene products in the tissue of HT. PTC in HT may be associated with HT.

关 键 词：HT 桥本甲状腺炎 甲状腺癌 临床病理研究 RET 临床表现 PTC 合并 结论 多样化 

分 类 号：R581[医药卫生—内分泌] R736.1[医药卫生—内科学]