兔肝VX2瘤移植前后肝血流动力学变化的多层CT灌注成像实验研究  

Experimental study on hemodynamic changes in liver before and after rabbit VX2 liver tumor inoculation by perfusion CT

作　　者：姜慧杰[1] 徐克[1] 刘瑞宝[2] 张慧博[1] 王强[1] 郭敏[1] 

机构地区：[1]中国医科大学附属第一医院放射科,辽宁沈阳110001 [2]哈尔滨医科大学附属第三医院放射科,黑龙江哈尔滨150040

出　　处：《中国医学影像技术》2005年第2期179-182,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨兔肝VX2移植瘤所引起的肝血流动力学变化规律.方法对10只新西兰大耳白兔在其接种VX2肿瘤前、后不同时间行肝多层螺旋CT灌注扫描,对比肝血流量(HBF)、血容积(HBV)、平均通过时间(MTT)、毛细血管表面通透性(PS)和肝动脉灌注指数(HAI)的变化规律.结果肿瘤边缘区与非肿瘤区比较:除MTT值降低以外(P＜0.01),其他各灌注值如HBF、HBV、HAI、PS均增高(P＜0.01).这些变化在接种后5～9天开始产生,随肿瘤生长,各灌注值均有改变,并有统计学意义(P＜0.05).结论兔肝VX2瘤移植前后可引起肝血流动力学改变,多层螺旋CT灌注成像可以评价肿瘤血管生成的生理学特性.Objective To study the rules of hemodynamic changes in liver caused by rabbit VX2 liver tumor with perfusion imaging of multi slice helical CT (MSCT). Methods Perfusion imaging of MSCT scans were conducted in 10 New Zealand white rabbits with VX2 tumor before and after VX2 liver tumor inoculation, the differences of perfusion parameters such as hepatic blood flow (HBF), hepatic blood volume (HBV), mean transit time (MTT), permeability of capillary vessel surface (PS) and hepatic arterial index (HAI) were compared to evaluate the liver hemodynamic changes. Results For tumorous regions in livers, only MTT decreased significantly ( P <0.01),the other values such as HBF, HBV, HAI, PS increased significantly ( P <0.01), when compared with the non tumorous regions in liver. All these changes occurred at days 5-9 after tumor inoculation. Statistically significant changes in these values were detected with tumor growth ( P <0.05). Conclusion The hemodynamic changes in liver caused by rabbit VX2 liver tumor can be detected before and after tumor inoculation. Perfusion imaging of MSCT can evaluate the physiological characters of tumor angiogenesis.

关 键 词：肝肿瘤 体层摄影术 X线计算机 血流动力学 动物模型 

分 类 号：Q95-33[生物学—动物学] R814.42[医药卫生—影像医学与核医学]