大鼠高原严重烧伤后早期肾组织损伤及复方红景天对其影响  

The Effect of Rhadiola Astragalus Codonopsis Compound(复方红景天) on Kidney Injury in Early Stage of Severe Burn at Plateau in Rats

作　　者：于晟[1] 薛晓东[2] 胡军[1] 杨生兰 张世范[1] 刘毅[1] 蔡黔[1] 张鲜英[1] 肖斌[1] 刘萍[1] 

机构地区：[1]兰州军区兰州总医院,兰州730050 [2]甘肃省人民医院,兰州730000 [3]甘肃省建筑职工医院,兰州730050

出　　处：《中国中医急症》2005年第3期256-257,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：全军"十五"医药卫生科研指令性课题基金资助项目(No.01-L003)

摘　　要：目的观察高海拔(3480m)地区大鼠30%TBSAⅢ度烧伤后肾脏损害的程度,探讨使用复方红景天后对大鼠肾脏损伤的作用机制。方法104只Wistar大鼠随机分为红景天组、盐水组各48只及正常对照组8只。正常对照组大鼠不作烧伤和其它处理,红景天组烧伤前1周予大鼠胃内灌注复方红景天液4ml、2次/d,盐水组灌注等量等渗盐水,分别于烧伤后3、6、12、24、48和72h剖腹摘除肾脏作病理学检查。结果盐水组烧伤后3h肾小球及肾小管即发生严重损伤,以肾小球为著;烧伤后72h尚未恢复正常。红景天组则损伤较轻,烧伤后48～72h肾小球结构基本恢复正常。结论复方红景天对大鼠高原严重烧伤后早期肾损伤有明显的保护作用。Objective:To investigate the severity of early kidney injury in rats with 30%full thickness burn at plateau (3480m) and the protective effects of Rhadiola Astragalus Codonopsis Compound(复方红景天,RACC) on the rat kidney injury.Methods:104 wistar rats with 30%full thickness burn were randomly divided into the RACC application group (R,n=48) and the scalding group (S,n=48),and another 8 healthy rats as the controlled group (C,n=8).RACC was garaged into the rats' stomach in R and isotonic saline in S respectively.But no treatment in C.Rats' kidney was harvested for pathomorphological examination in 3,6,12,24,48 and 72 postburn hours.Results:The injury of renal glomeruli and uriniferous tubule of ratsin S was obvious at 3 postoburn hours and the injury of renal glomeruli was more severe than the uriniferous fubule,and it wasn't to the normal condition at 72 postoburn hours.The injury of rats in R was slight and the construction of renal glomeruli was to the normal degree at 72 postoburn hours.Conclusion:RACC exhibited beneficial to the protection of rat kidney injury at plateau induced by severe burn.

关 键 词：烧伤 肾脏 高原 复方红景天 

分 类 号：R285.5[医药卫生—中药学]