番荔枝种子化学成分研究  

Chemical constituents from the seeds of Annona squamosa

作　　者：余竞光[1] 罗秀珍[1] 孙兰[1] 李德宇[1] 黄文华[1] 刘春雨[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药用植物研究所,北京100094

出　　处：《药学学报》2005年第2期153-158,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(29572087).

摘　　要：目的　研究药用植物番荔枝(AnnonasquamosaL)种子的抗肿瘤活性成分。方法　利用各种色谱技术进行分离纯化, 根据化合物的理化性质和光谱数据鉴定化学结构。结果　从乙醇提取物分离鉴定了 11个番荔素:squamocenin(1), annotemoyin- 2 (2), reticulatain- 2 (3), squamocin- I(4), squamocin -B(5), squamocin(6), motrilin(7), squamostatin -D(8), squamostatin- E(9), cherimolin -1 (10)和cherimolin -2 (11)。结论　Squamocenin(1)为新番荔素; annotemoyin- 2 (2)和reticulatain -2 (3)是首次报道该植物含有的化合物。Aim To study the antitumor active constituents of the seeds from Annona squamosa L. (Annonaceae). Methods Various chromatographic techniques were used to isolate and purify the constituents. Their physico-chemical properties and spectral data were determined to elucidate the structures. Results Eleven compounds were isolated and identified as annonaceous acetogenins: squamocenin (1), annotemoyin-2 (2), reticulatain-2 (3), squamocin-I (4), squamocin-B (5), squamocin (6), motrilin (7), squamostatin-D (8), squamostatin-E (9), cherimolin-1 (10), cherimolin-2 (11) from the ethyl alcohol extract of A.squamosa L. Conclusion Squamocenin (1) is a new acetogenin. Annotemoyin-2 (2) and reticulatain-2 (3) were isolated from this plant for the first time.

关 键 词：番荔枝 番荔枝科 番荔素 squamocenin annutemoyin-2 reticulatain-2 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]