水飞蓟素固体脂质纳米粒冻干工艺的研究  

Freeze-drying of silymarin-loaded solid lipid nanoparticles(SM-SLN)

作　　者：何军[1] 奉建芳[2] 张乐乐[2] 陆伟根[2] 侯世祥[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]上海医药工业研究院药物制剂部,上海200437

出　　处：《中国中药杂志》2005年第2期110-112,共3页China Journal of Chinese Materia Medica

基　　金：国家"8 63"计划项目 (2 0 0 1AA2 180 11) ;上海市纳米科技与产业发展促进中心项目 (0 14 3nm0 63 )

摘　　要：目的 :对水飞蓟素固体脂质纳米粒冻干工艺进行了研究。方法 :以外观、色泽、再分散性为指标 ,考察了不同种类的支架剂和浓度对纳米粒冻干剂的影响 ,并对冻干工艺参数进行了优化。结果 :2 %乳糖加 2 %葡萄糖作为支架剂可以较好防止纳米粒的聚集 ,优化的冻干工艺为 - 4 5℃预冻 10h ,升温至 - 2 5℃维持 5h ,再升温至 - 5℃维持 2h ,再升温至 10℃维持 2h ,最后升温至 30℃维持 6h。结论Objective: To investigate lyophilization of SM-SLN. Method: The parameters of lyophilization process was optimized. In addition, the protective effect of various types and concentrations of cryoprotectants were tested by shape,colour and disparity. Result: the mixture of 2% lactose and 2% glucose could better prevent nanoparticles from aggregating. the optimal lyophilization process was followed: precooled at -45 ℃ for 10 hr; primary drying at -25 ℃ for 5hr; secondary drying at 10 ℃ for 3hr; Finally drying at 30 ℃ for 6hr. Conclusion: Changes in particle size distribution during lyophilization could be minimized by optimizing the parameters of the lyophilization process and adding supporting agent.

关 键 词：固体脂质纳米粒 水飞蓟素 支架 升温 维持 葡萄糖 冻干工艺 浓度 筛选 种类 

分 类 号：TQ461[化学工程—制药化工]